Glucocorticoids, Sex Hormones, and Immunity.
Glucocorticoids, Sex Hormones, and Immunity.
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DOI：
10.3389/fimmu.2018.01332
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发表时间：
2018
影响因子：
7.3
通讯作者：
Riccardi C
中科院分区：
文献类型：
--
作者：
Bereshchenko O;Bruscoli S;Riccardi C
糖皮质激素调节哺乳动物的基本身体功能，控制细胞的新陈代谢、生长、分化和凋亡。重要的是，它们是有效的炎症抑制因子，涉及白细胞凋亡、分化和细胞因子产生的多种免疫调节机制已被描述。由于其强大的抗炎和免疫抑制活性，合成糖皮质激素(GCs)是治疗自身免疫性和炎症性疾病的最常用的处方药。长期以来，人们注意到，在几种自身免疫性疾病(AD)中，男性和女性的患病率存在差异。这可能是由于性激素在调节免疫反应中的作用，通过其内源性核受体来调节基因表达，并产生独特的性别特有的细胞环境。鉴于GCs是主要的生理抗炎激素，性激素也可能发挥免疫调节功能，GCs和性激素之间可能存在联系。了解这种可能的串扰的性质对于揭开阿尔茨海默病性别差异的原因并仔细开出这些治疗炎症性疾病的药物非常重要。在这篇综述中，我们讨论了性激素和GC对免疫系统的影响的异同，以突出功能相互作用的可能轴。
Glucocorticoid hormones regulate essential body functions in mammals, control cell metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors of inflammation, and multiple immune-modulatory mechanisms involving leukocyte apoptosis, differentiation, and cytokine production have been described. Due to their potent anti-inflammatory and immune-suppressive activity, synthetic glucocorticoids (GCs) are the most prescribed drugs used for treatment of autoimmune and inflammatory diseases. It is long been noted that males and females exhibit differences in the prevalence in several autoimmune diseases (AD). This can be due to the role of sexual hormones in regulation of the immune responses, acting through their endogenous nuclear receptors to mediate gene expression and generate unique gender-specific cellular environments. Given the fact that GCs are the primary physiological anti-inflammatory hormones, and that sex hormones may also exert immune-modulatory functions, the link between GCs and sex hormones may exist. Understanding the nature of this possible crosstalk is important to unravel the reason of sexual disparity in AD and to carefully prescribe these drugs for the treatment of inflammatory diseases. In this review, we discuss similarities and differences between the effects of sex hormones and GCs on the immune system, to highlight possible axes of functional interaction.
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DOI：
10.1073/pnas.040577497
发表时间：
2000-03-14
影响因子：
11.1
作者：
Bynoe, MS;Grimaldi, CM;Diamond, B
通讯作者：
Diamond, B
影响因子：
4.8
作者：
Bruscoli, Stefano;Velardi, Enrico;Riccardi, Carlo
通讯作者：
Riccardi, Carlo
影响因子：
12.4
作者：
Banuelos J;Cao Y;Shin SC;Lu NZ
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Lu NZ
影响因子：
14.9
作者：
Bolt MJ;Stossi F;Newberg JY;Orjalo A;Johansson HE;Mancini MA
通讯作者：
Mancini MA
影响因子：
4.4
作者：
Brewer, JA;Kanagawa, O;Muglia, LJ
通讯作者：
Muglia, LJ