Evoked and Induced Gamma-Frequency Oscillations in Autism
Evoked and Induced Gamma-Frequency Oscillations in Autism
复制标题
自闭症中诱发和诱发的伽马频率振荡
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
E. Sokhadze
中科院分区：
文献类型：
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作者：
M. Casanova;Joshua M. Baruth;A. El;Guela Sokhadze;M. K. Hensley;E. Sokhadze
我们小组最近的研究已经将自闭症的神经病理学特征描述为一种小型脊柱病。使用计算机图像分析锥体细胞阵列的死后研究发现，自闭症个体的大脑具有较小的微柱，大部分减少源于其外周神经元空间的减少，其核心空间很少减少。这一发现已被复制使用不同的技术（例如，GLI）和独立群体（Casanova等人，2002 a，B，c，2006 a，B）。现在已知自闭症的微柱宽度减少跨越颗粒上、颗粒和颗粒下层（Casanova等人，2010）。对这些发现最简单的解释是所有层共同的解剖元素可能异常。微柱的外周神经间隙提供了分布在其所有层中的抑制性成分。这就是Szentagothai和Arbib（1975）所描述的所谓的微柱抑制浴帘。因此，我们的研究结果表明，细胞微柱周围的抑制元件存在缺陷（Casanova et al. 2006 a）。
Recent studies by our group have characterized the neuropathology of autism as that of a minicolumnopathy. Postmortem studies using computerized image analysis of pyramidal cell arrays have found that the brains of autistic individuals have smaller minicolumns with most of the decrease stemming from a reduction in its peripheral neuropil space, with little, if any reduction, in their core space. This finding has been reproduced using different techniques (e.g., GLI) and independent populations (Casanova et al. 2002a, b, c, 2006a, b). It is now known that minicolumnar width reduction in autism spans supragranular, granular, and infragranular layers (Casanova et al. 2010). The most parsimonious explanation for the findings is the possible abnormality of an anatomical element in common to all layers. The peripheral neuropil space of minicolumns provides, among other things, for inhibitory elements distributed throughout all of its laminae. This is the so-called shower curtain of inhibition of the minicolumn described by Szentagothai and Arbib (1975). Our findings therefore suggest a deficit within the inhibitory elements that surround the cell minicolumn (Casanova et al. 2006a).
DOI：
10.1080/10874208.2010.501500
发表时间：
2010-07-01
期刊：
Journal of neurotherapy
影响因子：
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作者：
Baruth JM;Casanova MF;El-Baz A;Horrell T;Mathai G;Sears L;Sokhadze E
通讯作者：
Sokhadze E