Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer's disease
Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer's disease
复制标题
中国散发性阿尔茨海默病患者 CD2AP 基因表达降低
DOI：
10.1016/j.neurobiolaging.2017.03.013
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发表时间：
2017-08
影响因子：
4.2
通讯作者：
Wu ZY
中科院分区：
文献类型：
--
作者：
Tao QQ;Liu ZJ;Sun YM;Li HL;Yang P;Liu DS;Jiang B;Li XY;Xu JF;Wu ZY
在过去的几十年里，许多散发性阿尔茨海默病（SAD）的风险基因已经被确定，但其中大多数并没有被一致接受。在这里，我们试图确定SAD相关基因及其参与SAD发病的潜在机制。采用两阶段设计。在第1阶段，在1857名受试者（422名SAD患者和1435名对照）中评估了75个基因中的95个变异，这些基因先前被报道为高加索人群中的SAD风险基因。在第二阶段，在1001名受试者（254名SAD和747名对照组）的独立队列中进一步评估了在第一阶段发现的一组有希望的变异。在我们的受试者中，CD2AP变异与SAD风险显著相关。检测209例SAD患者和213例对照组外周血淋巴细胞（PBL）中CD2APgene的表达。与对照组相比，SAD患者PBL中CD2APgene表达明显降低。我们的研究表明，cd2apis是中国汉族人群中SAD的危险基因，而cd2apgene在SAD患者的PBL中表达降低，表明其可能参与了SAD的全体性作用。
Many sporadic Alzheimer's disease (SAD) risk genes have been identified in the last decades, but most of them have not been consistently accepted. Here, we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis. A 2-stage design was employed. In stage 1, 95 variants in 75 genes that were previously reported as SAD-risk genes in Caucasian populations were evaluated in 1857 subjects (422 SAD patients and 1435 controls). In stage 2, a subset of promising variants found in stage 1 were further evaluated in an independent cohort of 1001 subjects (254 SAD and 747 controls). Variants in CD2AP were significantly associated with SAD risk in our subjects. Furthermore,CD2APgene expression in peripheral blood lymphocytes (PBL) from 209 SAD patients and 213 controls was determined.CD2APgene expression in PBL was significantly decreased in patients with SAD as compared with controls. Our study suggests thatCD2APis an SAD-risk gene in Chinese Han population andCD2APgene expression is decreased in the PBL of patients with SAD, indicating its possible systemic involvement in SAD.
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影响因子：
15.9
作者：
Yaddanapudi, Suma;Altintas, Mehmet M.;Reiser, Jochen
通讯作者：
Reiser, Jochen
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
PhD A.M. Saunders;MD W.J. Strittmatter;MD D. Schmechel;P. H. St;MD M.A George-Hyslop;PhD S.H Pericak-Vance-PhD-S.H
通讯作者：
PhD A.M. Saunders;MD W.J. Strittmatter;MD D. Schmechel;P. H. St;MD M.A George-Hyslop;PhD S.H Pericak-Vance-PhD-S.H
中国男性全基因组关联研究确定了 9q31.2 和 19q13.4 两个新的前列腺癌风险位点
影响因子：
30.8
作者：
Xu J;Mo Z;Ye D;Wang M;Liu F;Jin G;Xu C;Wang X;Shao Q;Chen Z;Tao Z;Qi J;Zhou F;Wang Z;Fu Y;He D;Wei Q;Guo J;Wu D;Gao X;Yuan J;Wang G;Xu Y;Wang G;Yao H;Dong P;Jiao Y;Shen M;Yang J;Ou-Yang J;Jiang H;Zhu Y;Ren S;Zhang Z;Yin C;Gao X;Dai B;Hu Z;Yang Y;Wu Q;Chen H;Peng P;Zheng Y;Zheng X;Xiang Y;Long J;Gong J;Na R;Lin X;Yu H;Wang Z;Tao S;Feng J;Sun J;Liu W;Hsing A;Rao J;Ding Q;Wiklund F;Gronberg H;Shu XO;Zheng W;Shen H;Jin L;Shi R;Lu D;Zhang X;Sun J;Zheng SL;Sun Y
通讯作者：
Sun Y
影响因子：
30.8
作者：
Harold, Denise;Abraham, Richard;Hollingworth, Paul;Sims, Rebecca;Gerrish, Amy;Hamshere, Marian L.;Pahwa, Jaspreet Singh;Moskvina, Valentina;Dowzell, Kimberley;Williams, Amy;Jones, Nicola;Thomas, Charlene;Stretton, Alexandra;Morgan, Angharad R.;Lovestone, Simon;Powell, John;Proitsi, Petroula;Lupton, Michelle K.;Brayne, Carol;Rubinsztein, David C.;Gill, Michael;Lawlor, Brian;Lynch, Aoibhinn;Morgan, Kevin;Brown, Kristelle S.;Passmore, Peter A.;Craig, David;McGuinness, Bernadette;Todd, Stephen;Holmes, Clive;Mann, David;Smith, A. David;Love, Seth;Kehoe, Patrick G.;Hardy, John;Mead, Simon;Fox, Nick;Rossor, Martin;Collinge, John;Maier, Wolfgang;Jessen, Frank;Schuermann, Britta;van den Bussche, Hendrik;Heuser, Isabella;Kornhuber, Johannes;Wiltfang, Jens;Dichgans, Martin;Froelich, Lutz;Hampel, Harald;Huell, Michael;Rujescu, Dan;Goate, Alison M.;Kauwe, John S. K.;Cruchaga, Carlos;Nowotny, Petra;Morris, John C.;Mayo, Kevin;Sleegers, Kristel;Bettens, Karolien;Engelborghs, Sebastiaan;De Deyn, Peter P.;Van Broeckhoven, Christine;Livingston, Gill;Bass, Nicholas J.;Gurling, Hugh;McQuillin, Andrew;Gwilliam, Rhian;Deloukas, Panagiotis;Al-Chalabi, Ammar;Shaw, Christopher E.;Tsolaki, Magda;Singleton, Andrew B.;Guerreiro, Rita;Muehleisen, Thomas W.;Noethen, Markus M.;Moebus, Susanne;Joeckel, Karl-Heinz;Klopp, Norman;Wichmann, H-Erich;Carrasquillo, Minerva M.;Pankratz, V. Shane;Younkin, Steven G.;Holmans, Peter A.;O'Donovan, Michael;Owen, Michael J.;Williams, Julie
通讯作者：
Williams, Julie
影响因子：
5.3
作者：
Harrison, Benjamin J.;Venkat, Gayathri;Petruska, Jeffrey C.
通讯作者：
Petruska, Jeffrey C.