Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
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中国男性全基因组关联研究确定了 9q31.2 和 19q13.4 两个新的前列腺癌风险位点
DOI：
10.1038/ng.2424
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发表时间：
2012-11
期刊：
影响因子：
30.8
通讯作者：
Sun Y
中科院分区：
文献类型：
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作者：
Xu J;Mo Z;Ye D;Wang M;Liu F;Jin G;Xu C;Wang X;Shao Q;Chen Z;Tao Z;Qi J;Zhou F;Wang Z;Fu Y;He D;Wei Q;Guo J;Wu D;Gao X;Yuan J;Wang G;Xu Y;Wang G;Yao H;Dong P;Jiao Y;Shen M;Yang J;Ou-Yang J;Jiang H;Zhu Y;Ren S;Zhang Z;Yin C;Gao X;Dai B;Hu Z;Yang Y;Wu Q;Chen H;Peng P;Zheng Y;Zheng X;Xiang Y;Long J;Gong J;Na R;Lin X;Yu H;Wang Z;Tao S;Feng J;Sun J;Liu W;Hsing A;Rao J;Ding Q;Wiklund F;Gronberg H;Shu XO;Zheng W;Shen H;Jin L;Shi R;Lu D;Zhang X;Sun J;Zheng SL;Sun Y
利用全基因组关联研究(GWAS)，在欧洲血统、非裔美国人和日本人的人群中已有前列腺癌风险相关变异的报道。为了系统地研究中国男性前列腺癌风险相关变异，我们在中国汉族人中进行了首例前列腺癌风险相关变异研究。在4,484例前列腺癌患者和8,934名对照中，除了证实了其他祖先群体中报道的几个关联外，本研究还在染色体9q31.2(rs817826，P=5.45×10−14)和19q13.4(rs103294，P=5.34×10−16)上发现了两个新的前列腺癌风险相关基因。位于19q13.4的rs103294标记与6.7kb的生殖系缺失处于强连锁平衡状态，该缺失去除了调节炎症反应的基因LILRA3七个外显子中的前六个，并与T细胞中LILRA3mRNA的表达显著相关(P<；1×10−4)。这些发现可能会促进人们对前列腺癌遗传易感性的理解。
Prostate cancer risk–associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk–associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10−14) and 19q13.4 (rs103294, P = 5.34 × 10−16) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10−4). These findings may advance the understanding of genetic susceptibility to prostate cancer.
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DOI：
10.1093/bioinformatics/btq452
发表时间：
2010-10-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Yang TP;Beazley C;Montgomery SB;Dimas AS;Gutierrez-Arcelus M;Stranger BE;Deloukas P;Dermitzakis ET
通讯作者：
Dermitzakis ET
多阶段全基因组关联研究确定了七个前列腺癌易感位点
影响因子：
30.8
作者：
通讯作者：
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影响因子：
30.8
作者：
Zheng, Wei;Long, Jirong;Gao, Yu-Tang;Li, Chun;Zheng, Ying;Xiang, Yong-Bin;Wen, Wanqing;Levy, Shawn;Deming, Sandra L.;Haines, Jonathan L.;Gu, Kai;Fair, Alecia Malin;Cai, Qiuyin;Lu, Wei;Shu, Xiao-Ou
通讯作者：
Shu, Xiao-Ou
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
30.8
作者：
Yeager, Meredith;Chatterjee, Nilanjan;Ciampa, Julia;Jacobs, Kevin B.;Gonzalez-Bosquet, Jesus;Hayes, Richard B.;Kraft, Peter;Wacholder, Sholom;Orr, Nick;Berndt, Sonja;Yu, Kai;Hutchinson, Amy;Wang, Zhaoming;Amundadottir, Laufey;Feigelson, Heather Spencer;Thun, Michael J.;Diver, W. Ryan;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Schumacher, Fredrick R.;Cancel-Tassin, Geraldine;Cussenot, Olivier;Valeri, Antoine;Andriole, Gerald L.;Crawford, E. David;Haiman, Christopher A.;Henderson, Brian;Kolonel, Laurence;Le Marchand, Loic;Siddiq, Afshan;Riboli, Elio;Key, Timothy J.;Kaaks, Rudolf;Isaacs, William;Isaacs, Sarah;Wiley, Kathleen E.;Gronberg, Henrik;Wiklund, Fredrik;Stattin, Par;Xu, Jianfeng;Zheng, S. Lilly;Sun, Jielin;Vatten, Lars J.;Hveem, Kristian;Kumle, Merethe;Tucker, Margaret;Gerhard, Daniela S.;Hoover, Robert N.;Fraumeni, Joseph F., Jr.;Hunter, David J.;Thomas, Gilles;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.