The cimetidine-lidocaine interaction.
The cimetidine-lidocaine interaction.
复制标题
西咪替丁-利多卡因相互作用。
DOI：
10.7326/0003-4819-98-2-174
复制
发表时间：
1983
影响因子：
39.2
通讯作者：
J. Somberg
中科院分区：
文献类型：
--
作者：
A. Knapp;W. Maguire;G. Keren;A. Karmen;B. Levitt;D. Miura;J. Somberg
利多卡因是一种广泛使用的抗心律失常药物，其血浆清除率随肝血流变化而变化。西咪替丁，一种h2受体拮抗剂，已被证明可减少肝血流量。为了确定西咪替丁是否影响血清利多卡因浓度，我们将21例接受利多卡因输注的患者分为两组。15例患者在利多卡因基础上给予西咪替丁，每6小时300 mg；6例患者仅接受利多卡因治疗。在同时接受利多卡因和西咪替丁治疗的15名患者中，有14名患者的血清利多卡因水平升高，而对照组则没有变化。在15名患者中，有6人被发现有中毒水平，2人出现症状。另外三名接受利多卡因治疗的患者接受了苯海拉明（一种h1受体拮抗剂）治疗。给予苯海拉明后未发现血清利多卡因水平升高。我们认为，利多卡因和西咪替丁之间存在相互作用，血清利多卡因水平的升高可能是由西咪替丁抑制H2受体介导的。
Lidocaine is a widely used antiarrhythmic agent whose plasma clearance varies with changes in hepatic blood flow. Cimetidine, an H2-receptor antagonist, has been shown to decrease hepatic blood flow. To ascertain whether cimetidine affected serum lidocaine concentration, we studied 21 patients receiving lidocaine infusions and divided them into two groups. Fifteen patients received cimetidine, 300 mg every 6 hours, in addition to lidocaine; six patients received only lidocaine. In 14 of the 15 patients receiving both lidocaine and cimetidine, a rise in serum lidocaine levels was seen, whereas no change was noted in the control group. Six of the 15 patients were found to have levels in the toxic range and two had symptoms. An additional three patients on lidocaine received diphenhydramine, an H1-receptor antagonist. No elevation in serum lidocaine levels was noted after administration of diphenhydramine. We conclude that there exists an interaction between lidocaine and cimetidine and that the rise in serum lidocaine levels may be mediated by cimetidine's inhibition of the H2 receptor.
西咪替丁减少肝血流量和普萘洛尔代谢。
DOI：
10.1056/nejm198103193041202
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Feely,J;Wilkinson,GR;Wood,AJ
通讯作者：
Wood,AJ