Reduction of liver blood flow and propranolol metabolism by cimetidine.
Reduction of liver blood flow and propranolol metabolism by cimetidine.
复制标题
西咪替丁减少肝血流量和普萘洛尔代谢。
DOI：
10.1056/nejm198103193041202
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wood,AJ
中科院分区：
文献类型：
--
作者：
Feely,J;Wilkinson,GR;Wood,AJ
我们研究了西咪替丁对8名正常人肝血流量的影响。通过吲哚菁绿色清除率测定，西咪替丁急性减少禁食期间肝血流量近25%。慢性西咪替丁治疗（300毫克，每天4次，共7天）减少了33%的流量，通过计算口服和静脉注射普萘洛尔的相对处置，在8小时内测量。除了通过减少肝血流量减少静脉注射普萘洛尔的清除率外，西咪替丁还抑制口服普萘洛尔的代谢，从而进一步减少消除。口服普萘洛尔清除率的降低与西咪替丁稳态血药浓度呈正相关（r = 0.87，P<0.05），提示西咪替丁对药物代谢的抑制作用与剂量有关。普萘洛尔加西咪替丁治疗后静息脉率明显低于普萘洛尔单药治疗后。西咪替丁引起的肝血流量减少对肝脏和胃肠道血流量改变的患者以及使用肝脏消除依赖于肝血流量的药物的患者具有重要的治疗意义。（《新英格兰医学杂志》1981年; 304：692-5）
We studied the influence of cimetidine on liver blood flow in eight normal subjects. Cimetidine acutely reduced liver blood flow during fasting by almost 25 per cent, as measured by indocyanine green clearance. Chronic cimetidine therapy (300 mg four times daily for seven days) reduced the flow by 33 per cent, as measured over eight hours by calculating the relative disposition of oral and intravenous propranolol. In addition to reducing the clearance of intravenous propranolol by decreasing liver blood flow, cimetidine also inhibited the metabolism of oral propranolol and thereby further reduced elimination. The reduction in clearance of oral propranolol correlated positively (r = 0.87, P<0.05) with the average steady-state concentration of plasma cimetidine, suggesting that the inhibition of drug metabolism by cimetidine is dose related. Pulse rates at rest were markedly lower after propranolol plus cimetidine than after propranolol alone. The reduction in liver blood flow produced by cimetidine has important therapeutic implications for patients with alterations in liver and gastrointestinal blood flow and when drugs are used whose hepatic elimination depends on liver blood flow. (N Engl J Med. 1981; 304:692–5.)
登录
查看更多内容
西咪替丁导致地西泮的清除延迟。
影响因子：
158.5
作者：
U. Klotz;I. Reimann
通讯作者：
I. Reimann
肾功能衰竭对西咪替丁血液浓度的影响。
影响因子：
29.4
作者：
K. Ma;D. C. Brown;D. Masler;S. Silvis
通讯作者：
S. Silvis
猫胃血管中存在组胺 H1 和 H2 受体的证据
影响因子：
7.3
作者：
C. A. Harvey;D. Owen;K. Shaw
通讯作者：
K. Shaw
口服蛋白质和葡萄糖喂养对正常和肝硬化受试者内脏血流和氧利用的影响
DOI：
--
发表时间：
1955
期刊：
影响因子：
--
作者：
J. L. Brandt;L. Castleman;H. Ruskin;J. Greenwald;John J. Kelly;A. Jones
通讯作者：
A. Jones
肝硬化的肝循环和药物分布。
影响因子：
29.4
作者：
D. Shand
通讯作者：
D. Shand