Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
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DOI：
10.1016/j.jaci.2022.04.013
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Turner JH
中科院分区：
文献类型：
--
作者：
Chapurin N;Wu J;Labby AB;Chandra RK;Chowdhury NI;Turner JH
慢性鼻窦炎（CRS）的特征是鼻窦炎和上呼吸道持续的局部区域粘膜炎症，具有大量相关的医疗费用。结合分子生物标志物、表型和炎症内型的个性化护理方法是目前研究的主要焦点，同时靶向治疗和生物治疗的兴起有可能迅速推进护理和改善结果。最近的研究结果表明，提高对CRS表型和内源性异质性的理解，并结合这些治疗干预措施，最终，这些个性化的方法有可能针对特定的炎症途径，提高疗效，降低成本，并限制副作用。本文综述了CRS表型、内源性和生物标志物的鉴定和表征的最新进展，并对靶向治疗的潜在意义进行了综述。
Chronic rhinosinusitis (CRS) is characterized by persistent locoregional mucosal inflammation of the paranasal sinuses and upper airway that has substantial associated health care costs. Personalized approaches to care that incorporate use of molecular biomarkers, phenotypes and inflammatory endotypes is a major focus of research at this time, and the concurrent rise of targeted therapeutics and biologic therapies has the potential to rapidly advance care and improve outcomes. Recent findings suggest that improved understanding of CRS phenotypic and endotypic heterogeneity, and incorporation of these therapeutic interventions Ultimately, these personalized approaches have the potential to target specific inflammatory pathways, increase efficacy, reduce costs, and limit side effects. This review summarizes recent advances in the identification and characterization of CRS phenotypes, endotypes, and biomarkers and reviews potential implications for targeted therapeutics.
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