Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.
Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.
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DOI：
10.1016/j.immuni.2018.05.011
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发表时间：
2018-06-19
期刊：
影响因子：
32.4
通讯作者：
Hsieh CS
中科院分区：
文献类型：
--
作者：
Perry JSA;Russler-Germain EV;Zhou YW;Purtha W;Cooper ML;Choi J;Schroeder MA;Salazar V;Egawa T;Lee BC;Abumrad NA;Kim BS;Anderson MS;DiPersio JF;Hsieh CS
The development of T cell tolerance in the thymus requires the presentation of host proteins by multiple antigen-presenting cell (APC) types. However, the importance of transferring host antigens from transcription factor AIRE-dependent medullary thymic epithelial cells (mTECs) to bone marrow (BM) APCs is unknown. We report that antigen was primarily transferred from mTECs to CD8α+dendritic cells (DCs) and showed that CD36, a scavenger receptor selectively expressed on CD8α+DCs, mediated the transfer of cell-surface, but not cytoplasmic, antigens. The absence of CD8α+DCs or CD36 altered thymic T cell selection, as evidenced by TCR repertoire analysis and the loss of allo-tolerance in murine allogeneic BM transplantation (allo-BMT) studies. Decreases in these DCs and CD36 expression in peripheral blood of human allo-BMT patients correlated with graft-versus-host disease. Our findings suggest that CD36 facilitates transfer of mTEC-derived cell-surface antigen on CD8α+DCs to promote tolerance to host antigens during homeostasis and allo-BMT.
影响因子：
32.4
作者：
Perry JSA;Russler-Germain EV;Zhou YW;Purtha W;Cooper ML;Choi J;Schroeder MA;Salazar V;Egawa T;Lee BC;Abumrad NA;Kim BS;Anderson MS;DiPersio JF;Hsieh CS
通讯作者：
Hsieh CS