Connections of the superior paraolivary nucleus of the rat: projections to the inferior colliculus.
Connections of the superior paraolivary nucleus of the rat: projections to the inferior colliculus.
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DOI：
10.1016/j.neuroscience.2009.06.030
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发表时间：
2009-09-29
期刊：
影响因子：
3.3
通讯作者：
Berrebi, A. S.
中科院分区：
文献类型：
--
作者：
Saldana, E.;Aparicio, M. -A.;Fuentes-Santamaria, V.;Berrebi, A. S.
关键词：
GABA能神经传递有助于形成下丘(IC)神经元的反应特性。在啮齿动物中，上橄榄旁核(SPON)是上橄榄复合体中一个突出的、定义明确的细胞群，它向IC发送重要的、但经常被忽视的GABA能投射。为了研究这些投射的轨迹、分布和形态，我们将神经解剖学示踪剂生物素化的葡聚糖胺注射到白化大鼠的脊椎。结果表明：1)脊束密集分布于同侧丘脑核的中央核(CNIC)、背侧皮质(DCIC)和外侧皮质(ECIC)。SPON还通过IC的连合将稀疏投影发送到对侧DCIC。2)Spon轴突较粗(直径1.2μm)，上升至外侧丘系内侧的中脑顶盖，大部分不支配外侧丘系的核。(3)Spon纤维在颈内动脉内大量分支，并具有丰富的前束和末梢。4)在同侧内核内，SPON的离散区神经元轴突形成两个层状终末神经丛：一个横跨CNIC和DCIC的内侧丛，与已知的CNIC的纤维树突板平行；一个外侧丛，位于ECIC内，方向与IC表面大致平行。5)SPON向同侧IC的投射是地形性的：内侧Spon神经元支配CNIC和DCIC的腹内侧区和ECIC的腹外侧区，而更多位于外侧的Spon神经元支配CNIC和DCIC的更多背外侧区和ECIC的更多背内侧区。因此，SPON纤维在IC内的分布模式与先前报道的滑膜内和皮质小脑投射相似。
GABAergic neurotransmission contributes to shaping the response properties of inferior colliculus (IC) neurons. In rodents, the superior paraolivary nucleus (SPON) is a prominent and well-defined cell group of the superior olivary complex that sends significant but often neglected GABAergic projections to the IC. To investigate the trajectory, distribution and morphology of these projections, we injected the neuroanatomical tracer biotinylated dextran amine into the SPON of albino rats. Our results demonstrate that: 1) The SPON innervates densely all three subdivisions of the ipsilateral IC: central nucleus (CNIC), dorsal cortex (DCIC) and external cortex (ECIC). The SPON also sends a sparse projection to the contralateral DCIC via the commissure of the IC. 2) SPON axons are relatively thick (diameter > 1.2 μm), ascend to the midbrain tectum in the medial aspect of the lateral lemniscus, and, for the most part, do not innervate the nuclei of the lateral lemniscus. 3) SPON fibers ramify profusely within the IC and bear abundant en passant and terminal boutons. 4) The axons of neurons in discrete regions of the SPON form two laminar terminal plexuses in the ipsilateral IC: a medial plexus that spans the CNIC and DCIC parallel to the known fibrodendritic laminae of the CNIC, and a lateral plexus located in the ECIC and oriented more or less parallel to the surface of the IC. 5) The projection from SPON to the ipsilateral IC is topographic: medial SPON neurons innervate the ventromedial region of the CNIC and DCIC and the ventrolateral region of the ECIC, whereas more laterally situated SPON neurons innervate more dorsolateral regions of the CNIC and DCIC and more dorsomedial regions of the ECIC. Thus, SPON fibers follow a pattern of distribution within the IC similar to that previously reported for intracollicular and corticocollicular projections.
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DOI：
10.1007/bf00319050
发表时间：
1985-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
FAYELUND, H;OSEN, KK
通讯作者：
OSEN, KK
影响因子：
2.9
作者：
BEYERL, BD
通讯作者：
BEYERL, BD
影响因子：
2.5
作者：
ADAMS, JC
通讯作者：
ADAMS, JC
影响因子：
2.5
作者：
Behrend, O;Brand, A;Grothe, B
通讯作者：
Grothe, B
影响因子：
2.5
作者：
FRISINA, RD;ONEILL, WE;ZETTEL, ML
通讯作者：
ZETTEL, ML