Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison.
Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison.
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用于肝细胞癌诊断、预后和治疗的生物标志物 MicroRNA：功能调查和比较
DOI：
10.1038/srep38311
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发表时间：
2016-12-05
影响因子：
4.6
通讯作者：
Shen B
中科院分区：
文献类型：
--
作者：
Shen S;Lin Y;Yuan X;Shen L;Chen J;Chen L;Qin L;Shen B
肝细胞癌（HCC）是最常见的恶性肿瘤之一，发病率和死亡率较高。因此，迫切需要精确有效的生物标志物来进行早期诊断和预后评估。 MicroRNA (miRNA) 是重要的调节因子，在各种细胞过程和生物活动中发挥作用。越来越多的证据表明miRNA的异常表达与HCC的发生和进展密切相关。近年来，许多HCC生物标志物miRNA已从血液或组织样本中鉴定出来，但其临床病理特征的普遍性和特异性研究较少。在这篇综述中，我们根据癌症标志、病因因素以及种族群体，全面调查和比较了血液和组织中HCC生物标志物miRNA的诊断、预后和治疗作用，这将有助于了解HCC发展中生物标志物miRNA的发病机制，并进一步为HCC诊断和治疗提供准确的临床决策。
Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed for the early diagnosis and prognostic estimation. MicroRNAs (miRNAs) are important regulators which play functions in various cellular processes and biological activities. Accumulating evidence indicated that the abnormal expression of miRNAs are closely associated with HCC initiation and progression. Recently, many biomarker miRNAs for HCC have been identified from blood or tissues samples, however, the universality and specificity on clinicopathological features of them are less investigated. In this review, we comprehensively surveyed and compared the diagnostic, prognostic, and therapeutic roles of HCC biomarker miRNAs in blood and tissues based on the cancer hallmarks, etiological factors as well as ethnic groups, which will be helpful to the understanding of the pathogenesis of biomarker miRNAs in HCC development and further provide accurate clinical decisions for HCC diagnosis and treatment.
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影响因子：
2.9
作者：
Fu Y;Wei X;Tang C;Li J;Liu R;Shen A;Wu Z
通讯作者：
Wu Z
影响因子：
2.4
作者：
El-Garem, Hassan;Ammer, Ayman;Omar, Heba
通讯作者：
Omar, Heba
MiR-125a异位表达通过靶向MMP11和VEGF抑制肝细胞癌的增殖和转移
影响因子：
3.7
作者：
Bi Q;Tang S;Xia L;Du R;Fan R;Gao L;Jin J;Liang S;Chen Z;Xu G;Nie Y;Wu K;Liu J;Shi Y;Ding J;Fan D
通讯作者：
Fan D
影响因子：
2.5
作者：
Das T;Diamond DL;Yeh M;Hassan S;Bryan JT;Reyes JD;Perkins JD
通讯作者：
Perkins JD
癌症在基因水平或通路水平的分子特征？
影响因子：
--
作者：
Chen J;Wang Y;Shen B;Zhang D
通讯作者：
Zhang D