Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data.
Molecular signature of cancer at gene level or pathway level? Case studies of colorectal cancer and prostate cancer microarray data.
复制标题
癌症在基因水平或通路水平的分子特征？
DOI：
10.1155/2013/909525
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发表时间：
2013
影响因子：
--
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Chen J;Wang Y;Shen B;Zhang D
随着最近微阵列技术的进步，基因组规模的癌症分子签名鉴定得到了蓬勃发展。然而，不同实验室获得的差异表达基因差异很大。目前在基因水平上的差异表明需要一种新的策略来获得更强大的癌症信号。在本文中，我们假设(1)不同癌症微阵列数据集的表达特征在途径水平上比在基因水平上更相似；(2)不同个体癌症分子机制的相似性与他们的遗传相似性有关。为了支持假设，我们总结了理论和实验证据，并对结直肠癌和前列腺癌微阵列数据集进行了案例研究。基于上述假设，我们建议应该在遗传同质性人群的队列中，在生物途径的背景下研究可靠的癌症信号。希望这些假说能够指导未来癌症机制和信号发现的研究。
With recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for a novel strategy to obtain more robust signatures for cancer. In this paper we hypothesize that (1) the expression signatures of different cancer microarray datasets are more similar at pathway level than at gene level; (2) the comparability of the cancer molecular mechanisms of different individuals is related to their genetic similarities. In support of the hypotheses, we summarized theoretical and experimental evidences, and conducted case studies on colorectal and prostate cancer microarray datasets. Based on the above assumption, we propose that reliable cancer signatures should be investigated in the context of biological pathways, within a cohort of genetically homogeneous population. It is hoped that the hypotheses can guide future research in cancer mechanism and signature discovery.
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影响因子：
11.5
作者：
Hong, Yi;Ho, Kok Sun;Cheah, Peh Yean
通讯作者：
Cheah, Peh Yean
影响因子：
168.9
作者：
Michiels, S;Koscielny, S;Hill, C
通讯作者：
Hill, C
影响因子：
--
作者：
Galamb O;Györffy B;Sipos F;Spisák S;Németh AM;Miheller P;Tulassay Z;Dinya E;Molnár B
通讯作者：
Molnár B
影响因子：
56.9
作者：
Tomlins, SA;Rhodes, DR;Chinnaiyan, AM
通讯作者：
Chinnaiyan, AM
DOI：
10.1073/pnas.0601231103
发表时间：
2006-04-11
影响因子：
11.1
作者：
Ein-Dor, L;Zuk, O;Domany, E
通讯作者：
Domany, E