Using novel methods to examine stress among HIV-positive African American men who have sex with men and women.
Using novel methods to examine stress among HIV-positive African American men who have sex with men and women.
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DOI：
10.1007/s10865-012-9421-5
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发表时间：
2013-06
影响因子：
3.1
通讯作者：
Kisler KA
中科院分区：
文献类型：
--
作者：
Glover DA;Williams JK;Kisler KA
客观量化心理社会压力的生物标志物复合物（BC）独立于自我报告，可以帮助识别那些最有可能出现负面健康结果的人，并阐明压力相关过程的机制。在这里，BC检查艾滋病毒阳性的非洲裔美国男性之间的现有疾病进展的背景下，与男性和女性（MSMW）有高压力的历史，包括儿童性虐待。参与者（N = 99）收集了12小时的过夜和早晨尿液样本，用于测定皮质醇和儿茶酚胺（原发性BC）和新蝶呤（HIV疾病进展的指标）。还收集了累积心理社会创伤史（严重程度、类型、频率、首次发病年龄）、创伤后应激障碍（PTSD）症状、性风险行为和由常规健康指标（心率、血压、体重指数、腰臀比）组成的二级BC的数据。终生创伤暴露是非常普遍的，在那些符合PTSD病例标准截止值的人中显着更高（24%）。在控制HIV因素（新喋呤水平和患病年限）后，PTSD是原发性BC的显著预测因子（p <0.05），但不是继发性BC的预测因子。与没有PTSD的人相比，那些患有PTSD的人也有更多的性伴侣，没有安全套的性行为，以及用性换取金钱或毒品。在回归模型中，特定的创伤特征独立且唯一地预测了PTSD的严重程度和病例数（p <0.05 - 0.001）。一个主要的BC出现敏感的累积创伤负担和创伤后应激障碍在HIV阳性的非洲裔美国MSMW，提供支持使用BC量化心理社会压力和通知新的方法来检查机制的压力影响健康行为和疾病的结果在高危人群。
Biomarker composites (BCs) that objectively quantify psychosocial stress independent of self report could help to identify those at greatest risk for negative health outcomes and elucidate mechanisms of stress-related processes. Here, BCs are examined in the context of existing disease progression among HIV-positive African American men who have sex with men and women (MSMW) with high stress histories, including childhood sexual abuse. Participants (N = 99) collected 12-h overnight and morning urine samples for assay of cortisol and catecholamines (primary BC) and neopterin (an indicator of HIV disease progression). Data on cumulative psychosocial trauma history (severity, types, frequency, age at first incident), posttraumatic stress disorder (PTSD) symptoms, sexual risk behaviors, and a secondary BC consisting of routine health indicators (heart rate, blood pressure, body mass index, waist-to-hip ratio) were also collected. Lifetime trauma exposure was highly pervasive and significantly greater among those meeting a standard cutoff for PTSD caseness (24 %). After controlling for HIV factors (neopterin levels and years with disease), PTSD was a significant (p <.05) predictor of the primary, but not secondary BC. Those with PTSD also had significantly more sexual partners, sex without a condom, and exchange sex for money or drugs than those without PTSD. Specific trauma characteristics predicted PTSD severity and caseness independently and uniquely in regression models (p’s <.05–.001). A primary BC appears sensitive to cumulative trauma burden and PTSD in HIV-positive African American MSMW, providing support for the use of BCs to quantify psychosocial stress and inform novel methods for examining mechanisms of stress influenced health behaviors and disease outcomes in at-risk populations.
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DOI：
10.1046/j.1365-2362.2002.01068.x
发表时间：
2002-10-01
影响因子：
5.5
作者：
Christeff, N;de Truchis, P;Gougeon, ML
通讯作者：
Gougeon, ML
影响因子：
5.1
作者：
Friedrich, W N;Fisher, J L;Wright, J
通讯作者：
Wright, J
影响因子：
3.3
作者：
Follette, VM;Polusny, MA;Naugle, AE
通讯作者：
Naugle, AE
影响因子：
4.4
作者：
Glover, Dorie A.;Garcia-Aracena, Elena F.;Lester, Patricia;Rice, Eric;Rothram-Borus, Mary Jane
通讯作者：
Rothram-Borus, Mary Jane
DOI：
10.1080/15299730903502920
发表时间：
2010
期刊：
Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)
影响因子：
--
作者：
Glover DA;Loeb TB;Carmona JV;Sciolla A;Zhang M;Myers HF;Wyatt GE
通讯作者：
Wyatt GE