Stress biomarkers as outcomes for HIV+ prevention: participation, feasibility and findings among HIV+ Latina and African American mothers.
Stress biomarkers as outcomes for HIV+ prevention: participation, feasibility and findings among HIV+ Latina and African American mothers.
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DOI：
10.1007/s10461-009-9549-7
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发表时间：
2010-04
影响因子：
4.4
通讯作者：
Rothram-Borus, Mary Jane
中科院分区：
文献类型：
--
作者：
Glover, Dorie A.;Garcia-Aracena, Elena F.;Lester, Patricia;Rice, Eric;Rothram-Borus, Mary Jane
鉴于与艾滋病毒状况、种族、经济和城市生活条件相关的挑战，感染艾滋病毒（MLH）的母亲面临急性和慢性压力的高风险。生物标志物组合成一个复合指数在量化健康人的社会心理压力方面显示出希望，但尚未在MLH中进行研究。根据这项研究，我们在100名贫困的非裔美国人和拉丁裔母亲（MLH）和人口统计学匹配的对照组母亲（n = 50）中检测了压力的潜在生物标志物相关性[从家中收集的尿液和基本健康指标（血压、身高和体重、腰臀比）中测量的皮质醇和儿茶酚胺]。参与者在大约18个月前参加了一项随机对照试验，要么接受了（MLH-I），要么正在等待（MLH-W）心理社会干预。参与率高，93%的病例正确收集了生物标志物，并计算了133名母亲（平均年龄= 42）的完整复合生物标志物指数（CBI）。正如预测的那样，MLH的CBI明显高于对照组，但不同种族或干预组的CBI没有差异。在控制了年龄、诊断后的年数、既往CD4计数、药物依从性和抑郁症状后，CBI独立预测了CD4计数。该研究证明了以社区为基础的生物标志物收集在评估心理社会压力个体差异方面的可接受性、可行性和潜在效用。
Mothers living with HIV (MLH) are at high risk for acute and chronic stress, given challenges related to their HIV status, ethnicity, economic and urban living conditions. Biomarkers combined into a composite index show promise in quantifying psychosocial stress in healthy people, but have not yet been examined among MLH. According, we examined potential biomarker correlates of stress [cortisol and catecholamines from home-collected urine and basic health indicators (blood pressure, height and weight, waist-to-hip ratio) measured during an interview] among 100 poor African American and Latina mothers MLH and demographic-matched control mothers without HIV (n = 50). Participants had been enrolled in a randomized controlled trial about 18 months earlier and had either received (MLH-I) or were awaiting (MLH-W) the psychosocial intervention. Participation was high, biomarkers were correctly collected for 93% of cases, and a complete composite biomarker index (CBI) calculated for 133 mothers (mean age = 42). As predicted, MLH had a significantly higher CBI than controls, but there was no CBI difference across ethnicity or intervention group. CBI predicted CD4 counts independently after controlling for age, years since diagnosis, prior CD4 counts, medication adherence, and depression symptoms. The study demonstrates acceptability, feasibility and potential utility of community-based biomarker collections in evaluating individual differences in psychosocial stress.
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