The design and synthesis of a soluble composite silica xerogel and the short-time release of proteins.
The design and synthesis of a soluble composite silica xerogel and the short-time release of proteins.
复制标题
可溶性复合二氧化硅干凝胶的设计与合成及蛋白质的短时释放。
DOI：
10.1039/c4tb01622j
复制
发表时间：
2015-04
影响因子：
7
通讯作者：
Ducheyne, Paul
中科院分区：
文献类型：
--
作者：
Chen, Rong;Qu, Haibo;Guo, Shaoyun;Ducheyne, Paul
Conventional silica xerogels prepared through sol-gel processing are regarded as suitable materials for the long-term release of proteins due to the mild processing conditions. However, they fall short of short-time release of these large molecules because of their small pore size and a slow dissolution rate. With the goal of achieving controlled release of large molecules (such as proteins) in a very short time (several days), herein we focus on the co-hydrolysis and co-condensation of different precursors to synthesize composite xerogels (co-xerogels) with adjustable degradation rates. Tetraethoxysilane and 3-(triethoxysilyl) propylsuccinic anhydride were employed to prepare the co-xerogels. Succinic anhydride was chosen due to its potential to crosslink with Si-OH and to integrate into the silica network under acidic conditions. Using the trypsin inhibitor (TI) as a model drug to characterize the release properties of co-xerogels, we obtained tailored release behavior of TI (2-7 days). It is demonstrated that the co-hydrolysis and co-condensation of different precursors is an easy technique that further expands the applicability of sol-gel materials as excellent carriers for the controlled release of a variety of drugs.
登录
查看更多内容
影响因子：
3.3
作者：
M. Prokopowicz
通讯作者：
M. Prokopowicz
影响因子：
2.5
作者：
N. Moussa;A. Ghorbel;P. Grange
通讯作者：
N. Moussa;A. Ghorbel;P. Grange
影响因子：
9.7
作者：
Radin, Shula;Bhattacharyya, Sanjib;Ducheyne, Paul
通讯作者：
Ducheyne, Paul
影响因子：
3.2
作者：
Czarnobaj, Katarzyna
通讯作者：
Czarnobaj, Katarzyna
影响因子：
10.8
作者：
De la Riva, Beatriz;Sanchez, Esther;Evora, Carmen
通讯作者：
Evora, Carmen