Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study.
Outcome of lifestyle intervention in relation to duration of pre-diabetes: the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) study.
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DOI：
10.1136/bmjdrc-2021-002748
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发表时间：
2022-03
影响因子：
4.1
通讯作者：
Wan J
中科院分区：
文献类型：
--
作者：
Dagogo-Jack S;Umekwe N;Brewer AA;Owei I;Mupparaju V;Rosenthal R;Wan J
在招募病程未知的糖尿病前期患者的研究中，生活方式干预(LI)延缓了大多数参与者发展为2型糖尿病(T2D)的时间，但没有逆转糖尿病前期。在这里，我们评估了LI对已知病程的糖尿病前期患者的影响，以确定预后是否与糖尿病前期的病程有关。在一项双列队列研究中，糖尿病前期的病理生物学和可逆性在最初血糖正常的非洲裔美国人和父母为T2D的欧洲裔美国人的随访中启动了LI。参与者被分成那些在糖尿病前诊断后3年、3-5年或5年后开始LI的人。评估包括人体测量、体脂、空腹和2小时血糖(FPG，2hPG)以及胰岛素敏感性和分泌。结果是正常的血糖调节(NGR；即正常的空腹血糖和2hPG)，持续性糖尿病前期，或T2D。在随访期间维持正常空腹血糖和正常2hPG水平的受试者作为对照。对照组受试者没有接受生活方式或其他干预来改变血糖或体重的进程。2 2 3例受试者(年龄5 3.3±9.2 8岁，体重指数30.6±6.70 kg/m2)，72例(对照组)在随访期间血糖维持在正常范围，138例糖尿病前期患者在确诊后4.0 8±2.0 2年(3个月~8.3年)开始发生LI。与对照组相比，LI参与者的血糖、体重和体脂减少；42.8%的人恢复到NGR，50%的人持续有糖尿病前期，7.2%的人在5年后发展为T2D。这些结果在种族和糖尿病前病程层次上是相似的，但在糖尿病前诊断后5年内开始LI时，血糖下降幅度更大。在父母为T2D的成年人中，在发展为糖尿病前期的3个月至8.3年内开始LI的93%没有进展到T2D；近一半恢复到NGR。试用注册号NCT02027571。
In studies that enrolled people with prevalent pre-diabetes of unknown duration, lifestyle intervention (LI) delayed progression to type 2 diabetes (T2D) but did not reverse pre-diabetes in most participants. Here, we assessed the effects of LI among individuals with pre-diabetes of known duration to determine whether outcomes are related to duration of pre-diabetes. The Pathobiology and Reversibility of Prediabetes in a Biracial Cohort study initiated LI in subjects with incident pre-diabetes during follow-up of initially normoglycemic African Americans and European Americans with parental T2D. Participants were stratified into those initiating LI after <3, 3–5, or >5 years of pre-diabetes diagnosis. Assessments included anthropometry, body fat, fasting and 2-hour plasma glucose (FPG, 2hPG), and insulin sensitivity and secretion. The outcomes were normal glucose regulation (NGR; ie, normal FPG and 2hPG), persistent pre-diabetes, or T2D. Participants who maintained normal FPG and normal 2hPG levels during follow-up served as the control. The control subjects did not receive lifestyle or other intervention to alter the course of glycemia or body weight. Of 223 participants (age 53.3±9.28 years, body mass index 30.6±6.70 kg/m2), 72 (control) maintained normoglycemia during follow-up and 138 subjects with incident pre-diabetes initiated LI after 4.08±2.02 years (range 3 months–8.3 years) of diagnosis. Compared with control, LI participants showed decrease in glucose, weight, and body fat; 42.8% reverted to NGR, 50% had persistent pre-diabetes, and 7.2% developed T2D after 5 years. These outcomes were similar across race and pre-diabetes duration strata, but greater glycemic decrease occurred when LI was initiated within 5 years of pre-diabetes diagnosis. Ninety-three per cent of adults with parental T2D who initiated LI within 3 months to 8.3 years of developing pre-diabetes did not progress to T2D; nearly half reverted to NGR. Trial registration number NCT02027571.
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影响因子：
3
作者：
Edeoga, Chimaroke;Owei, Ibiye;Dagogo-Jack, Sam
通讯作者：
Dagogo-Jack, Sam
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
DOI：
10.1016/j.ecl.2017.10.001
发表时间：
2018-03
影响因子：
4.5
作者：
Brannick B;Dagogo-Jack S
通讯作者：
Dagogo-Jack S
影响因子：
8.2
作者：
ERIKSSON, KF;LINDGARDE, F
通讯作者：
LINDGARDE, F
影响因子：
4.1
作者：
Jiang Y;Owei I;Wan J;Ebenibo S;Dagogo-Jack S
通讯作者：
Dagogo-Jack S