25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
复制标题
DOI：
10.1016/j.mayocp.2017.07.016
复制
发表时间：
2017-11
影响因子：
8.9
通讯作者：
Sidney S
中科院分区：
文献类型：
--
作者：
Laddu DR;Rana JS;Murillo R;Sorel ME;Quesenberry CP Jr;Allen NB;Gabriel KP;Carnethon MR;Liu K;Reis JP;Lloyd-Jones D;Carr JJ;Sidney S
评估从青年到中年的25年体力活动(PA)轨迹，并评估与冠状动脉钙化(CAC)患病率的关系。CARDIA研究的3,175名参与者在25年(1985年3月至1986年6月至2010年6月至2011年5月)的8次随访检查中通过问卷自报PA。使用计算机断层摄影术测量25岁时CAC(CAC>；0)的存在。使用基于群体的轨迹建模来确定PA轨迹随年龄增长的情况。我们确定了3种不同的PA轨迹：轨迹1：低于PA指南(n=1813；57.1%)；轨迹2：符合PA指南(n=1094；34.5%)；以及轨迹3：3次PA指南(n=268；8.4%)。轨迹3参与者与轨迹1参与者相比，调整后的CAC>；0(AOR 1.27；95%CI：0.95，1.70)更高。按种族分层显示，参与PA三次的白人患CAC>；0的OR为1.80(95%CI：1.21，2.67)。按性别进一步分层显示白人男性的风险更高(OR 1.86；95%CI：1.16，2.98)，而白人女性也有类似但不显著的趋势(OR 1.71；95%CI：0.79，3.71)。然而，对于黑人参与者来说，没有观察到轨迹3的CAC>；0的几率更高。年龄在25岁以上、参加过3次PA推荐指南的白人，在中年时发生冠状动脉亚临床动脉粥样硬化的几率更高。这些发现值得进一步探索，特别是通过种族，探讨在PA水平非常高的情况下CAC风险的可能生物学机制。
To evaluate 25-year physical activity (PA) trajectories from young to middle-age and assess associations with the prevalence of coronary arterial calcification (CAC). 3,175 participants in CARDIA study self-reported PA by questionnaire at 8 follow up exams over 25 years (March 1985- June 1986 to June 2010-May 2011). The presence of CAC (CAC>0) at year 25 was measured using computed tomography. Group-based trajectory modeling was used to identify PA trajectories with increasing age. We identified 3 distinct PA trajectories: Trajectory 1: Below PA guidelines (n= 1813; 57.1%); Trajectory 2: Meeting PA guidelines (n= 1094; 34.5%); and, Trajectory 3: Three times PA guidelines (n= 268; 8.4%). Trajectory 3 participants had higher adjusted odds of CAC>0 (AOR 1.27; 95% CI: 0.95, 1.70) versus those in Trajectory 1. Stratification by race showed that whites engaged in PA three times the guidelines had higher odds of developing CAC>0 with OR 1.80 (95% CI: 1.21, 2.67). Further stratification by gender showed higher odds for white males (OR 1.86; 95% CI: 1.16, 2.98), while similar, but non- significant trends were noted for white females (OR 1.71; 95% CI: 0.79, 3.71). However, no such higher odds of CAC>0 for Trajectory 3 were observed for black participants. White individuals who participated in three times the recommended PA guidelines, over 25-years, had higher odds of developing coronary subclinical atherosclerosis by middle-age. These findings warrant further exploration, especially by race, into possible biological mechanisms for CAC risk at very high levels of PA.
登录
查看更多内容
影响因子：
19.7
作者：
Breuckmann, Frank;Moehlenkamp, Stefan;Barkhausen, Joerg
通讯作者：
Barkhausen, Joerg
影响因子：
2.8
作者：
Folsom, AR;Evans, GW;Stillman, AE
通讯作者：
Stillman, AE
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen
影响因子：
37.8
作者：
Bild, DE;Detrano, R;Saad, MF
通讯作者：
Saad, MF
影响因子：
11.1
作者：
Farahmand, BY;Ahlbom, A;Brobert, GP
通讯作者：
Brobert, GP