Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies.
Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies.
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通过重复的经颅磁刺激（RTMS）从抑郁症中恢复：临床前研究的系统综述和荟萃分析。
DOI：
10.1038/s41398-020-01055-2
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发表时间：
2020-11-10
影响因子：
6.8
通讯作者：
Zoratto F
中科院分区：
文献类型：
--
作者：
De Risio L;Borgi M;Pettorruso M;Miuli A;Ottomana AM;Sociali A;Martinotti G;Nicolò G;Macrì S;di Giannantonio M;Zoratto F
重复经颅磁刺激（rTMS）在治疗抑郁症（MDD）和难治性抑郁症（TRD）方面越来越受到关注。大多数关于rTMS的知识来自人体研究，因为临床前应用存在问题。然而，最近在动物模型中对rTMS的优化为改进翻译研究奠定了基础。临床前研究有可能帮助确定最佳刺激方案，并阐明rTMS使用的新的基于神经生物学的原理。为了评估rTMS对啮齿动物模型中抑郁样症状影响的现有证据，我们根据PRISMA指南（PROSPERO注册号：CRD 42019157549）进行了全面的文献检索。此外，我们进行了荟萃分析，以确定rTMS的疗效，进行亚组分析，以检查不同的实验模型和神经调节参数的影响。对抑郁样表型的评估是相当同质的，而23项纳入研究中的rTMS参数差异很大。大多数研究使用压力诱导模型。总体而言，结果显示，与假刺激相比，主动rTMS具有很大的有益效果，这反映在无助（SDM 1.34 [1.02;1.66]）和快感缺失（SDM 1.87 [1.02;2.72]）曲线的统计学显著性恢复中。在所有纳入的模型中均获得了抑郁样表型的改善，且与rTMS频率无关。尽管如此，这些结果对TRD患者的预测价值有限，因为仅使用抗抑郁药敏感模型。因此，将rTMS研究扩展到其他MDD模型（对应于不同的内在表型）和TRD模型对于测试rTMS疗效和开发具有成本效益的方案至关重要，并有可能在MDD和TRD中产生更快的临床反应。
Repetitive transcranial magnetic stimulation (rTMS) has gained growing interest for the treatment of major depression (MDD) and treatment-resistant depression (TRD). Most knowledge on rTMS comes from human studies as preclinical application has been problematic. However, recent optimization of rTMS in animal models has laid the foundations for improved translational studies. Preclinical studies have the potential to help identify optimal stimulation protocols and shed light on new neurobiological-based rationales for rTMS use. To assess existing evidence regarding rTMS effects on depressive-like symptoms in rodent models, we conducted a comprehensive literature search in accordance with PRISMA guidelines (PROSPERO registration number: CRD42019157549). In addition, we conducted a meta-analysis to determine rTMS efficacy, performing subgroup analyses to examine the impact of different experimental models and neuromodulation parameters. Assessment of the depressive-like phenotype was quite homogeneous whilst rTMS parameters among the 23 included studies varied considerably. Most studies used a stress-induced model. Overall, results show a largely beneficial effect of active rTMS compared to sham stimulation, as reflected in the statistically significant recovery of both helplessness (SDM 1.34 [1.02;1.66]) and anhedonic (SDM 1.87 [1.02;2.72]) profiles. Improvement of the depressive-like phenotype was obtained in all included models and independently of rTMS frequency. Nonetheless, these results have limited predictive value for TRD patients as only antidepressant-sensitive models were used. Extending rTMS studies to other MDD models, corresponding to distinct endophenotypes, and to TRD models is therefore crucial to test rTMS efficacy and to develop cost-effective protocols, with the potential of yielding faster clinical responses in MDD and TRD.
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影响因子：
2.9
作者：
Duprat R;De Raedt R;Wu GR;Baeken C
通讯作者：
Baeken C
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
10.6
作者：
Carola, Valeria;Frazzetto, Giovanni;Gross, Cornelius
通讯作者：
Gross, Cornelius
影响因子：
5.3
作者：
Gersner, Roman;Kravetz, Elena;Zangen, Abraham
通讯作者：
Zangen, Abraham
DOI：
10.1016/s0140-6736(17)32802-7
发表时间：
2018-04-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cipriani A;Furukawa TA;Salanti G;Chaimani A;Atkinson LZ;Ogawa Y;Leucht S;Ruhe HG;Turner EH;Higgins JPT;Egger M;Takeshima N;Hayasaka Y;Imai H;Shinohara K;Tajika A;Ioannidis JPA;Geddes JR
通讯作者：
Geddes JR