Different visual evoked potentials in neuromyelitis optica spectrum disorder-related optic neuritis and idiopathic demyelinating optic neuritis: a prospective longitudinal analysis.
Different visual evoked potentials in neuromyelitis optica spectrum disorder-related optic neuritis and idiopathic demyelinating optic neuritis: a prospective longitudinal analysis.
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视神经脊髓炎谱系疾病相关视神经炎和特发性脱髓鞘性视神经炎的不同视觉诱发电位：前瞻性纵向分析
DOI：
10.1186/s12886-022-02595-5
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发表时间：
2022-09-21
影响因子：
2
通讯作者：
Yang, Hui
中科院分区：
文献类型：
--
作者：
Zheng, Cong;Wang, Ling;Xu, Xiaoyu;Zhou, Manli;Liu, Kaiqun;Zhang, Yuxin;Zhao, Xiujuan;Lu, Lin;Qiu, Wei;Zhang, Xinyu;Yang, Hui
关键词：
目的探讨视神经肌萎缩性疾病相关性视神经炎（NMOSD-ON）和特发性脱髓鞘性视神经炎（IDON）的视觉诱发电位（VEP）特征。这是一项纵向、前瞻性、病例对照研究。84例急性视神经炎患者入组，其中NMOSD-ON患者26例，IDON患者58例。所有患者在发病时、1个月、3个月和6个月进行最佳矫正视力（BCVA）和全视野图形翻转VEP记录。在15次检查中，NMOSD-ON组患者6个月时VEP振幅降低更严重（2.39 ± 4.63 μV vs. 6.96 ± 8.88 μV，P = 0.034）。然而，IDON患者在3个月时VEP反应正常的频率更高（24.0% vs.4.5%，P = 0.017），而在6个月时仅P100峰潜伏期延长（30.0% vs.57.8%，P = 0.048）。在60′检查时间内，两组VEP参数在每次随访时均无显著性差异（P > 0.05）。 NMOSD-ON组轴突损伤较IDON组严重，轴突恢复较差。在NMOSD-ON中，较小的检查尺寸诱发的VEP对视觉通路异常更敏感。
To investigate different visual evoked potential (VEP) patterns in neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) and idiopathic demyelinating optic neuritis (IDON). This was a longitudinal, prospective, case-control study. Eighty-four Chinese patients with acute optic neuritis were enrolled, including 26 NMOSD-ON patients and 58 IDON patients. All the patients underwent best-corrected visual acuity (BCVA) and full-field pattern reversal VEP recordings at the onset, 1 month, 3 months, and 6 months. Within 15′ checks, the NMOSD-ON patients had more severe VEP amplitude reduction at 6 months (2.39 ± 4.63 μV vs. 6.96 ± 8.88 μV, P = 0.034). However, the IDON patients showed more frequently normal VEP response at 3 months (24.0% vs. 4.5%, P = 0.017), and only prolonged P100 peak latency with normal amplitude (L) at 6 months (30.0% vs. 57.8%, P = 0.048). Within 60′ checks, no significant difference in VEP parameters between the two groups was found at each follow-up (P > 0.05). The NMOSD-ON patients showed more severe axonal damage and worse axonal recovery than the IDON patients. VEP elicited by smaller check size was more sensitive to visual pathway abnormality in NMOSD-ON.
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影响因子：
9.9
作者：
Vidal-Jordana A;Rovira A;Arrambide G;Otero-Romero S;Río J;Comabella M;Nos C;Castilló J;Galan I;Cabello S;Moncho D;Rahnama K;Thonon V;Rodríguez-Acevedo B;Zabalza A;Midaglia L;Auger C;Sastre-Garriga J;Montalban X;Tintoré M
通讯作者：
Tintoré M
影响因子：
9.9
作者：
Wingerchuk DM;Banwell B;Bennett JL;Cabre P;Carroll W;Chitnis T;de Seze J;Fujihara K;Greenberg B;Jacob A;Jarius S;Lana-Peixoto M;Levy M;Simon JH;Tenembaum S;Traboulsee AL;Waters P;Wellik KE;Weinshenker BG;International Panel for NMO Diagnosis
通讯作者：
International Panel for NMO Diagnosis
影响因子：
9.9
作者：
Naismith, R. T.;Tutlam, N. T.;Cross, A. H.
通讯作者：
Cross, A. H.
影响因子：
4.4
作者：
Jones, SJ;Brusa, A
通讯作者：
Brusa, A
影响因子：
4.4
作者：
Schulze-Bonsel, K;Feltgen, N;Bach, M
通讯作者：
Bach, M