A non-invasive smart scaffold for bone repair and monitoring.
A non-invasive smart scaffold for bone repair and monitoring.
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一种用于骨修复和监测的非侵入性智能支架。
DOI：
10.1016/j.bioactmat.2022.04.034
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发表时间：
2023-01
影响因子：
18.9
通讯作者：
Ruan, Jing
中科院分区：
文献类型：
--
作者：
Huang, Yazhuo;Zhang, Lingyu;Ji, Yongrong;Deng, Hongpei;Long, Mingce;Ge, Shengfang;Su, Yanjie;Chan, Siew Yin;Loh, Xian Jun;Zhuang, Ai;Ruan, Jing
现有的骨缺损修复策略难以监测。能够量化新骨形成效率的智能支架材料对于骨再生和监测非常重要。碳纳米管具有良好的生物活性和导电性。在这项研究中，一个非侵入性和智能监测支架骨再生和监测的化学交联羧甲基壳聚糖水凝胶中整合羧基化碳纳米管。CNT支架（0.5%w/v）表现出改善的机械性能，具有良好的生物相容性和电化学响应性。循环伏安法和电化学阻抗谱显示，碳纳米管支架在细胞和动物水平上对种子细胞分化程度有敏感的响应。有趣的是，CNT支架可以通过CNT作用持续增强干细胞成骨分化和新骨组织形成来弥补骨形态发生蛋白2容易失活的不足。本研究为无创电化学响应生物活性支架的开发提供了新的思路，标志着智能组织工程的发展迈出了重要一步。在这项研究中，一个非侵入性和智能监测支架骨再生和监测的化学交联羧甲基壳聚糖水凝胶中集成碳纳米管。现有的骨缺损修复策略难以监测。本研究制备了一种无创性、智能化监测的骨再生支架。该支架是CNT整合到化学交联的羧甲基壳聚糖水凝胶中的组合。碳纳米管支架显示出改善的机械性能与生物相容性和电化学响应性。
Existing strategies for bone defect repair are difficult to monitor. Smart scaffold materials that can quantify the efficiency of new bone formation are important for bone regeneration and monitoring. Carbon nanotubes (CNT) have promising bioactivity and electrical conductivity. In this study, a noninvasive and intelligent monitoring scaffold was prepared for bone regeneration and monitoring by integrating carboxylated CNT into chemically cross-linked carboxymethyl chitosan hydrogel. CNT scaffold (0.5% w/v) demonstrated improved mechanical properties with good biocompatibility and electrochemical responsiveness. Cyclic voltammetry and electrochemical impedance spectroscopy of CNT scaffold responded sensitively to seed cell differentiation degree in both cellular and animal levels. Interestingly, the CNT scaffold could make up the easy deactivation shortfall of bone morphogenetic protein 2 by sustainably enhancing stem cell osteogenic differentiation and new bone tissue formation through CNT roles. This research provides new ideas for the development of noninvasive and electrochemically responsive bioactive scaffolds, marking an important step in the development of intelligent tissue engineering. In this study, a noninvasive and intelligent monitoring scaffold was prepared for bone regeneration and monitoring by integrating CNT into chemically cross-linked carboxymethyl chitosan hydrogel. Existing strategies for bone defect repair are difficult to monitor. In this study, a noninvasive and intelligent monitoring scaffold was prepared for bone regeneration and monitoring. This scaffold was a combination of CNT integrated into a chemically cross-linked carboxymethyl chitosan hydrogel. CNT scaffold showed improved mechanical properties with biocompatibility and electrochemical responsiveness.
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