Absolute quantification of myocardial perfusion under adenosine stress
Absolute quantification of myocardial perfusion under adenosine stress
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腺苷应激下心肌灌注的绝对定量
DOI：
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发表时间：
2006
影响因子：
3.3
通讯作者：
H. Köstler
中科院分区：
文献类型：
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作者：
C. Ritter;A. Brackertz;J. Sandstede;M. Beer;D. Hahn;H. Köstler
预推注技术允许人们通过 MRI 量化人类心脏的灌注，且变异性较低。在这项研究中，预推注技术用于确定腺苷应激下人心脏的定量灌注值并测量心肌灌注储备（MPR）。使用多层预推注技术和 1/4 cc Gd-BOPTA 对 12 名健康志愿者进行了检查。在休息和压力状态下，对 288 个手动分段的区域中的信号强度 (SI) 时间进程进行了评估。通过将 SI 时间进程与推注前扫描的动脉输入函数 (AIF) 进行解卷积来确定心肌灌注。平均应力灌注值为 1.78 ± 0.53cc/g/min，平均静息灌注值为 0.52 ± 0.11cc/g/min，平均 MPR 为 3.59 ± 1.26。测量值与动物模型和人体正电子发射断层扫描 (PET) 研究的数据密切相关。 Magn Reson Med，2006 年。© 2006 Wiley-Liss, Inc.
The prebolus technique allows one to quantify perfusion in the human heart with a low variability by means of MRI. In this study the prebolus technique was used to determine quantitative perfusion values in the human heart under adenosine stress and to measure the myocardial perfusion reserve (MPR). Twelve healthy volunteers were examined using the multislice prebolus technique with 1/4 cc Gd‐BOPTA. Signal intensity (SI) time courses were evaluated in 288 manually segmented sectors at rest and stress. Myocardial perfusion was determined by deconvolution of the SI time courses with the arterial input function (AIF) from the prebolus scan. The mean stress perfusion value was 1.78 ± 0.53cc/g/min, and the mean rest perfusion was 0.52 ± 0.11cc/g/min, resulting in a mean MPR of 3.59 ± 1.26. The measured values correlate well with data from animal models and human positron emission tomography (PET) studies. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
影响因子：
19.7
作者：
Wilke, N;JeroschHerold, M;Wilson, RF
通讯作者：
Wilson, RF
影响因子：
6.7
作者：
Schaefer,S;Lange,RA;Gutekunst,DP;Parkey,RW;Willerson,JT;Peshock,RM
通讯作者：
Peshock,RM