Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system
Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system
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rGDF11 通过抗氧化系统的作用延缓雄性小鼠的衰老过程
DOI：
10.1007/s10522-019-09799-1
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发表时间：
2019-02
期刊：
影响因子：
4.5
通讯作者：
Zhang Shicui
中科院分区：
文献类型：
--
作者：
Zhou Yang;Song Lili;Ni Shousheng;Zhang Yu;Zhang Shicui
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Current studies have generated disputes on the effects of GDF11 and GDF8, a closely related member of GDF11, on rejuvenation and anti-aging properties. In this study, we first demonstrated that when recombinant GDF8 (rGDF8) and GDF11 (rGDF11) of the fishNothobranchius guentheriwere injected into 20-month-old male mice, their serum GDF8 and GDF11 levels were clearly increased. We also showed that injection of rGDF8 and rGDF11 had little influences on the body weight and serological parameters of the mice, indicating their general condition and physiology were not affected. Based on these findings, we started to test the effects of administration of piscine rGDF11 and rGDF8 on the aging process of male mice and to explore the underlying mechanisms. It was found that rGDF11 was able to reduce the levels of AGEs, protein oxidation and lipid peroxidation, and to slow down the accumulation of age-related histological markers, while rGDF8 was not. Moreover, rGDF11 significantly prevented the decrease in CAT, GPX and SOD activities, but rGDF8 did not. Collectively, these results suggest that it is GDF11 but not GDF8 that can exert rejuvenation and anti-aging activities via the action of antioxidant system. It is also the first report that shows the activity of GDF11 is not species-specific, implicating potential usefulness of piscine GDF11 in prolonging the lifespan of the elderly.
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GDF11 的晚发给药可延长一年生鱼类 Nothobranchius guentheri 的寿命并延迟年龄相关标记的发育
影响因子：
4.5
作者：
Zhou Yang;Ni Shousheng;Song Lili;Wang Xia;Zhang Yu;Zhang Shicui
通讯作者：
Zhang Shicui
影响因子：
20.1
作者：
Poggioli T;Vujic A;Yang P;Macias-Trevino C;Uygur A;Loffredo FS;Pancoast JR;Cho M;Goldstein J;Tandias RM;Gonzalez E;Walker RG;Thompson TB;Wagers AJ;Fong YW;Lee RT
通讯作者：
Lee RT
影响因子：
3.9
作者：
Xin Yu;Guo-rong Li
通讯作者：
Xin Yu;Guo-rong Li
影响因子：
20.1
作者：
Smith SC;Zhang X;Zhang X;Gross P;Starosta T;Mohsin S;Franti M;Gupta P;Hayes D;Myzithras M;Kahn J;Tanner J;Weldon SM;Khalil A;Guo X;Sabri A;Chen X;MacDonnell S;Houser SR
通讯作者：
Houser SR
影响因子：
29
作者：
Egerman MA;Cadena SM;Gilbert JA;Meyer A;Nelson HN;Swalley SE;Mallozzi C;Jacobi C;Jennings LL;Clay I;Laurent G;Ma S;Brachat S;Lach-Trifilieff E;Shavlakadze T;Trendelenburg AU;Brack AS;Glass DJ
通讯作者：
Glass DJ