Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri
Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri
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GDF11 的晚发给药可延长一年生鱼类 Nothobranchius guentheri 的寿命并延迟年龄相关标记的发育
DOI：
10.1007/s10522-018-09789-9
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发表时间：
2018-12
期刊：
影响因子：
4.5
通讯作者：
Zhang Shicui
中科院分区：
文献类型：
--
作者：
Zhou Yang;Ni Shousheng;Song Lili;Wang Xia;Zhang Yu;Zhang Shicui
Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Importantly, we demonstrated that dietary intake of recombinant GDF11 had little influences on the body weight and length of aging N. guentheri, but it delayed the development of age-related biomarkers and extended both the median and maximum life span of the fish. Our results clearly demonstrate that piscine GDF11 has rejuvenation and anti-aging capacity, the first data as such in non-mammalian vertebrates.
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影响因子：
4.3
作者：
D. Valenzano;A. Cellerino
通讯作者：
D. Valenzano;A. Cellerino
影响因子：
20.1
作者：
Poggioli T;Vujic A;Yang P;Macias-Trevino C;Uygur A;Loffredo FS;Pancoast JR;Cho M;Goldstein J;Tandias RM;Gonzalez E;Walker RG;Thompson TB;Wagers AJ;Fong YW;Lee RT
通讯作者：
Lee RT
影响因子：
20.1
作者：
Smith SC;Zhang X;Zhang X;Gross P;Starosta T;Mohsin S;Franti M;Gupta P;Hayes D;Myzithras M;Kahn J;Tanner J;Weldon SM;Khalil A;Guo X;Sabri A;Chen X;MacDonnell S;Houser SR
通讯作者：
Houser SR
非洲绿松石杀死基因组提供了对生命周期进化和遗传结构的见解。
影响因子：
64.5
作者：
Valenzano DR;Benayoun BA;Singh PP;Zhang E;Etter PD;Hu CK;Clément-Ziza M;Willemsen D;Cui R;Harel I;Machado BE;Yee MC;Sharp SC;Bustamante CD;Beyer A;Johnson EA;Brunet A
通讯作者：
Brunet A
影响因子：
2.6
作者：
Xia Wang;Qingyun Chang;Yu Wang;F. Su;Shicui Zhang
通讯作者：
Xia Wang;Qingyun Chang;Yu Wang;F. Su;Shicui Zhang