Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque.
Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque.
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恒河猴基因组序列及550万个SNP的全序列变异图
DOI：
10.1186/gb-2011-12-7-r63
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发表时间：
2011-07-06
期刊：
影响因子：
12.3
通讯作者：
Su B
中科院分区：
文献类型：
--
作者：
Fang X;Zhang Y;Zhang R;Yang L;Li M;Ye K;Guo X;Wang J;Su B
BackgroundRhesus macaque (Macaca mulatta) is the most widely used nonhuman primate animal in biomedical research. A global map of genetic variations in rhesus macaque is valuable for both evolutionary and functional studies.ResultsUsing next-generation sequencing technology, we sequenced a Chinese rhesus macaque genome with 11.56-fold coverage. In total, 96% of the reference Indian macaque genome was covered by at least one read, and we identified 2.56 million homozygous and 2.94 million heterozygous SNPs. We also detected a total of 125,150 structural variations, of which 123,610 were deletions with a median length of 184 bp (ranging from 25 bp to 10 kb); 63% of these deletions were located in intergenic regions and 35% in intronic regions. We further annotated 5,187 and 962 nonsynonymous SNPs to the macaque orthologs of human disease and drug-target genes, respectively. Finally, we set up a genome-wide genetic variation database with the use of Gbrowse.ConclusionsGenome sequencing and construction of a global sequence variation map in Chinese rhesus macaque with the concomitant database provide applicable resources for evolutionary and biomedical research.
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影响因子：
14.9
作者：
Jegga AG;Gowrisankar S;Chen J;Aronow BJ
通讯作者：
Aronow BJ
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
MAMUSNP：一种用于恒河猴（Macaca Mulatta）基因组学的资源。
影响因子：
3.7
作者：
Malhi, Ripan S.;Sickler, Brad;Lin, Dawei;Satkoski, Jessica;Tito, Raul Y.;George, Debbie;Kanthaswamy, Sreetharan;Smith, David Glenn
通讯作者：
Smith, David Glenn
影响因子：
4.8
作者：
Chan, Anthony W. S.;Yang, Shang-Hsun
通讯作者：
Yang, Shang-Hsun
影响因子：
5.8
作者：
Loots, Gabriela;Ovcharenko, Ivan
通讯作者：
Ovcharenko, Ivan