Generation of transgenic monkeys with human inherited genetic disease.
Generation of transgenic monkeys with human inherited genetic disease.
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DOI：
10.1016/j.ymeth.2009.05.007
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发表时间：
2009-09
期刊：
影响因子：
4.8
通讯作者：
Yang, Shang-Hsun
中科院分区：
文献类型：
--
作者：
Chan, Anthony W. S.;Yang, Shang-Hsun
在过去的几十年里，有报道称，使用黑猩猩、恒河猴、食蟹猴、绒猴和松鼠等非人类灵长类动物来模拟人类疾病。由于非人灵长类动物与人类在基因组组成、认知行为功能、解剖结构、代谢、生殖和脑功能等方面具有很高的相似性，非人灵长类动物在理解人体的生理功能、阐明人类疾病的潜在机制以及开发治疗人类疾病的新方法方面发挥了重要作用。然而，由于非人类灵长类动物基因转移技术的局限性，非人类灵长类动物的研究仅限于人类疾病的认知、行为、生化和药理学方法。转基因技术的最新进展导致了2001年第一只转基因猴子的诞生和2008年亨廷顿病(HD)转基因猴子模型的诞生，改变了这一焦点。复制人类HD患者关键病理特征的转基因HD猴子的创建进一步表明，非人灵长类在未来生物医学的发展中发挥着关键作用。这些成功为在非人类灵长类动物中进行基因操作打开了大门，并在模拟人类遗传性遗传疾病方面进入了一个新时代。我们专注于创造转基因亨廷顿病猴子的程序，但我们的工作也可以应用于其他非人类灵长类物种的转基因。
Modeling human diseases using nonhuman primates including chimpanzee, rhesus, cynomolgus, marmoset and squirrel monkeys has been reported in the past decades. Due to the high similarity between nonhuman primates and humans, including genome constitution, cognitive behavioral functions, anatomical structure, metabolic, reproductive, and brain functions; nonhuman primates have played an important role in understanding physiological functions of the human body, clarifying the underlying mechanism of human diseases, and the development of novel treatments for human diseases. However, nonhuman primate research has been restricted to cognitive, behavioral, biochemical and pharmacological approaches of human diseases due to the limitation of gene transfer technology in nonhuman primates. The recent advancement in transgenic technology that has led to the generation of the first transgenic monkey in 2001 and a transgenic monkey model of Huntington's disease (HD) in 2008 has changed that focus. The creation of transgenic HD monkeys that replicate key pathological features of human HD patients further suggests the crucial role of nonhuman primates in the future development of biomedicine. These successes have opened the door to genetic manipulation in nonhuman primates and a new era in modeling human inherited genetic disorders. We focused on the procedures in creating transgenic Huntington's disease monkeys, but our work can be applied to transgenesis in other nonhuman primate species.
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影响因子：
4.2
作者：
Andreadis, S;Palsson, BO
通讯作者：
Palsson, BO
DOI：
10.1089/15204559950020076
发表时间：
1999-01-01
期刊：
Cloning
影响因子：
--
作者：
Chan, A W
通讯作者：
Chan, A W
DOI：
10.1186/1477-7827-2-39
发表时间：
2004-06-16
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Chan, Anthony W S
通讯作者：
Chan, Anthony W S
DOI：
10.1073/pnas.95.24.14028
发表时间：
1998-11-24
影响因子：
11.1
作者：
Chan, AWS;Homan, EJ;Bremel, RD
通讯作者：
Bremel, RD
影响因子：
1.5
作者：
Yang, Shang-Hsun;Agca, Yuksel;Chan, Anthony Wing Sang
通讯作者：
Chan, Anthony Wing Sang