Expression of transforming growth factor-β1 during diabetic renal hypertrophy

Expression of transforming growth factor-β1 during diabetic renal hypertrophy
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糖尿病肾肥大过程中转化生长因子-β1的表达

DOI:
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发表时间:
1994
期刊:
影响因子:
--
通讯作者:
K. Thai
K. Thai
中科院分区:
--
文献类型:
--
作者:
S. Shankland;J. Scholey;H. Ly;K. Thai

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Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Experimental type I diabetes mellitus is characterized by an early increase in kidney weight and glomerular volume, but changes in gene expression accompanying diabetic renal growth have not been fully elucidated. In the current study, total RNA was extracted from renal cortex and isolated glomeruli of streptozotocin-induced diabetic rats 24 hours, 48 hours, 96 hours, one and two weeks after the onset of hyperglycemia (blood glucose >15 mmol/liter), insulin-treated diabetic rats (blood glucose
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