Schizophrenic: forever young?
Schizophrenic: forever young?
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DOI：
10.1186/gm153
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发表时间：
2010-05-18
期刊：
影响因子：
12.3
通讯作者：
Le Novère N
中科院分区：
文献类型：
--
作者：
Baldi BF;Hoyer C;Le Novère N
精神分裂症是一种多因素复杂疾病，对社会影响巨大。多年来，人们提出了许多假说来解释其原因，基因组学和功能基因组学方法可能会揭示这些争议和差异背后的原因。我们给出了几种方法的概述，这些方法已被用于确定疾病的遗传原因和分子表型。我们关注Torkamani及其同事最近对正常和精神分裂症大脑中调节网络进化的微阵列分析。结合该研究的结论与精神分裂症的普遍假设，我们认为精神分裂症患者的大脑可能类似于青少年的大脑。
Schizophrenia is a multifactorial complex disease with a large impact on society. Many hypotheses have been proposed over the years to explain its causes, and genomics and functional genomic approaches may shed light on the reason behind these controversies and discrepancies. We give an overview of several approaches that have been used to identify the genetic causes and molecular phenotypes of the disease. We focus on a recent microarray analysis by Torkamani and colleagues on the evolution of regulatory networks in normal and schizophrenic brains. Combining the conclusion of that study with the prevalent hypotheses of schizophrenia, we suggest that the schizophrenic brain might resemble a juvenile brain.
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影响因子：
7
作者：
Torkamani, Ali;Dean, Brian;Thomas, Elizabeth A.
通讯作者：
Thomas, Elizabeth A.
影响因子：
--
作者：
Sullivan, PF;Kendler, KS;Neale, MC
通讯作者：
Neale, MC
影响因子：
46.9
作者：
Taylor, Chris F.;Field, Dawn;Sansone, Susanna-Assunta;Aerts, Jan;Apweiler, Rolf;Ashburner, Michael;Ball, Catherine A.;Binz, Pierre-Alain;Bogue, Molly;Booth, Tim;Brazma, Alvis;Brinkman, Ryan R.;Clark, Adam Michael;Deutsch, Eric W.;Fiehn, Oliver;Fostel, Jennifer;Ghazal, Peter;Gibson, Frank;Gray, Tanya;Grimes, Graeme;Hancock, John M.;Hardy, Nigel W.;Hermjakob, Henning;Julian, Randall K., Jr.;Kane, Matthew;Kettner, Carsten;Kinsinger, Christopher;Kolker, Eugene;Kuiper, Martin;Le Novere, Nicolas;Leebens-Mack, Jim;Lewis, Suzanna E.;Lord, Phillip;Mallon, Ann-Marie;Marthandan, Nishanth;Masuya, Hiroshi;McNally, Ruth;Mehrle, Alexander;Morrison, Norman;Orchard, Sandra;Quackenbush, John;Reecy, James M.;Robertson, Donald G.;Rocca-Serra, Philippe;Rodriguez, Henry;Rosenfelder, Heiko;Santoyo-Lopez, Javier;Scheuermann, Richard H.;Schober, Daniel;Smith, Barry;Snape, Jason;Stoeckert, Christian J., Jr.;Tipton, Keith;Sterk, Peter;Untergasser, Andreas;Vandesompele, Jo;Wiemann, Stefan
通讯作者：
Wiemann, Stefan
影响因子：
9.8
作者：
Shifman, S;Bronstein, M;Darvasi, A
通讯作者：
Darvasi, A
影响因子：
11
作者：
Prabakaran, S;Swatton, JE;Bahn, S
通讯作者：
Bahn, S