Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.
Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.
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DOI：
10.1016/j.yfrne.2012.09.003
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发表时间：
2012-08
影响因子：
7.4
通讯作者：
Miller AH
中科院分区：
文献类型：
--
作者：
Felger JC;Miller AH
数据表明，炎症反应期间释放的细胞因子靶向皮质下结构，包括基底神经节以及多巴胺功能，以急性诱导支持对抗感染和伤口愈合的行为变化。然而，慢性炎症和暴露于炎性细胞因子似乎会导致基底神经节和多巴胺功能的持续改变，表现为快感缺乏、疲劳和精神发育迟缓。此外，减少神经反应的享乐奖励，减少多巴胺代谢物在脑脊液中和增加突触前多巴胺摄取和减少营业额已被描述。基底神经节和多巴胺功能的这种多样性变化表明炎性细胞因子对多巴胺合成、包装、释放和/或再摄取的基本作用，这可能破坏和规避当前治疗方法的功效。因此，检查细胞因子改变基底神经节和多巴胺功能的机制将产生新的见解来治疗尼古丁诱导的行为变化和炎症性不适。
Data suggest that cytokines released during the inflammatory response target subcortical structures including the basal ganglia as well as dopamine function to acutely induce behavioral changes that support fighting infection and wound healing. However, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. Moreover, reduced neural responses to hedonic reward, decreased dopamine metabolites in the cerebrospinal fluid and increased presynaptic dopamine uptake and decreased turnover have been described. This multiplicity of changes in the basal ganglia and dopamine function suggest fundamental effects of inflammatory cytokines on dopamine synthesis, packaging, release and/or reuptake, which may sabotage and circumvent the efficacy of current treatment approaches. Thus, examination of the mechanisms by which cytokines alter the basal ganglia and dopamine function will yield novel insights into the treatment of cytokine-induced behavioral changes and inflammatory malaise.
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DOI：
10.1016/j.ijrobp.2007.05.076
发表时间：
2007-12-01
影响因子：
7
作者：
Butler, Jerome M., Jr.;Case, L. Douglas;Shaw, Edward G.
通讯作者：
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影响因子：
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影响因子：
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影响因子：
3.3
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影响因子：
3.8
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