Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice.
Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice.
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DOI：
10.1093/jhered/esab009
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发表时间：
2021-05-24
期刊：
影响因子：
--
通讯作者：
MacManes MD
中科院分区：
文献类型：
--
作者：
Colella JP;Tigano A;Dudchenko O;Omer AD;Khan R;Bochkov ID;Aiden EL;MacManes MD
气候变暖和荒漠化加剧，迫切需要鉴定与耐热和耐脱水相关的基因，以便更好地为生物多样性保护工作提供信息并确定目标。现存适应沙漠的物种之间的比较可以通过识别共同的选择特征来突出基因组进化的平行或趋同模式。我们为峡谷小鼠（Peromyscus crinitus）生成了染色体级基因组组装，并通过比较来自另一同属沙漠专家（Peromyscus eremicus）和广泛分布的栖息地通才（Peromyscus maniculatus）的群体水平基因组重测序数据的选择性扫描特征来测试平行进化的特征，这些特征可能局部适应 干旱的条件。我们发现很少有参与沙漠适应的共享候选基因座，并且没有找到对并行进化的共享模式的支持。相反，我们假设鹿鼠之间沙漠适应的不同分子机制，可能与特定物种的历史人口统计有关，这可能会限制或增强适应。我们确定了一些在 P. crinitus 基因组中经历选择性扫描的候选位点，这些位点与渗透调节（胰蛋白酶、前列腺素）和代谢调节（激肽释放酶、eIF2-α 激酶 GCN2、APPL1/2）有关，这对于适应炎热和干燥的环境条件可能很重要。
Warming climate and increasing desertification urge the identification of genes involved in heat and dehydration tolerance to better inform and target biodiversity conservation efforts. Comparisons among extant desert-adapted species can highlight parallel or convergent patterns of genome evolution through the identification of shared signatures of selection. We generate a chromosome-level genome assembly for the canyon mouse (Peromyscus crinitus) and test for a signature of parallel evolution by comparing signatures of selective sweeps across population-level genomic resequencing data from another congeneric desert specialist (Peromyscus eremicus) and a widely distributed habitat generalist (Peromyscus maniculatus), that may be locally adapted to arid conditions. We identify few shared candidate loci involved in desert adaptation and do not find support for a shared pattern of parallel evolution. Instead, we hypothesize divergent molecular mechanisms of desert adaptation among deer mice, potentially tied to species-specific historical demography, which may limit or enhance adaptation. We identify a number of candidate loci experiencing selective sweeps in the P. crinitus genome that are implicated in osmoregulation (Trypsin, Prostasin) and metabolic tuning (Kallikrein, eIF2-alpha kinase GCN2, APPL1/2), which may be important for accommodating hot and dry environmental conditions.
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影响因子：
56.9
作者：
Chen, I-Ching;Hill, Jane K.;Thomas, Chris D.
通讯作者：
Thomas, Chris D.
影响因子：
14.9
作者：
Bult CJ;Blake JA;Smith CL;Kadin JA;Richardson JE;Mouse Genome Database Group
通讯作者：
Mouse Genome Database Group
影响因子：
3.3
作者：
Bassham, Susan;Catchen, Julian;Cresko, William A.
通讯作者：
Cresko, William A.
DOI：
10.1073/pnas.1120523109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Cheviron, Zachary A.;Bachman, Gwendolyn C.;Storz, Jay F.
通讯作者：
Storz, Jay F.
影响因子：
5.8
作者：
Danecek, Petr;Auton, Adam;Durbin, Richard
通讯作者：
Durbin, Richard