Alcohol intoxication increases allopregnanolone levels in male adolescent humans
Alcohol intoxication increases allopregnanolone levels in male adolescent humans
复制标题
酒精中毒会增加男性青少年的异孕酮水平
DOI：
10.1007/s00213-003-1662-0
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发表时间：
2004
影响因子：
3.4
通讯作者：
E. Ortega
中科院分区：
文献类型：
--
作者：
J. M. Torres;E. Ortega
理性青少年饮酒在工业化国家日益引起人们的担忧，这些国家近35%的饮酒者年龄在16岁以下。青少年焦虑、易怒和抑郁的增加可能会促使他们寻求酒精的抗焦虑和奖励特性。Allopregnanolone是有益的啮齿动物，因此可能有助于酒精的影响。Allopregnanolone在本文中，我们研究了急性酒精中毒对血浆水平的影响allopregnanolone在男性adolescents.MethodsBlood样本从男性青少年谁到达急诊科的医院。研究了两组：一个研究组由有明显急性酒精中毒（AAI）行为症状的青少年组成，另一个研究组由轻度创伤的青少年组成（挫伤、扭伤）不饮酒后结果我们的结果表明，AAI显着增加血清allopregnanolone水平在男性adolescents. Conclusions因为酒精和allopregnanolone积极调节γ-氨基丁酸A型（GABAA）受体，别孕烯醇酮可能直接或通过影响GABAA受体对酒精的敏感性，在酒精的抗焦虑和奖励作用中起主要作用。
RationaleTeenage drinking is a cause of growing concern in industrialized countries, where almost 35% of alcohol drinkers are under 16 years old. Increased anxiety, irritability and depression among adolescents may induce them to seek the anxiolytic and rewarding properties of alcohol. Allopregnanolone is rewarding in rodents, and therefore may contribute to the effects of alcohol.ObjectiveIn this paper, we studied the effects of acute alcohol intoxication on the plasma levels of allopregnanolone in male adolescents.MethodsBlood samples were drawn from male adolescents who arrived at the Emergency Department of the Hospital. Two groups were studied: one study group was formed by adolescents who arrived with evident behavioral symptoms of acute alcohol intoxication (AAI) and the other by those arriving for mild trauma (contusions, sprains) after no consumption of alcohol (Controls).ResultsOur results demonstrate that AAI significantly increases serum allopregnanolone levels in male adolescents.ConclusionsBecause alcohol and allopregnanolone positively modulate gamma-aminobutyric acid type A (GABAA) receptors, allopregnanolone may play a major role in the anxiolytic and rewarding effects of alcohol, either directly or by influencing the sensitivity of GABAA receptors to alcohol.
对 6 年级至 12 年级学生的酒精使用和滥用情况进行了测量。
DOI：
10.1111/j.1530-0277.1994.tb00938.x
发表时间：
1994
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Shope,JT;Copeland,LA;Dielman,TE
通讯作者：
Dielman,TE