Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease.
Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease.
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DOI：
10.1093/cercor/bht140
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Timmermann L
中科院分区：
文献类型：
--
作者：
Herz DM;Florin E;Christensen MS;Reck C;Barbe MT;Tscheuschler MK;Tittgemeyer M;Siebner HR;Timmermann L
运动前区和运动皮质区之间的有效神经通信对于手动运动控制至关重要。在这里，我们使用高密度脑电图来研究帕金森病（PD）患者和年龄匹配的健康对照者的皮层连接，同时他们以最大重复率进行右手食指的重复运动。使用多源波束形成器分析和动态因果建模来评估对侧半球中的外侧运动前皮层（lPM）、辅助运动区（SMA）和初级运动皮层（M1）之间的振荡耦合。老年健康对照组在lPM到SMA和M1的连接中显示出与任务相关的调制，主要在γ波段（>30 Hz）内。未用药的PD患者也显示出从lPM到M1的任务相关的γ-γ偶联，但不存在从lPM到SMA的γ偶联。左旋多巴恢复了lPM与SMA之间的生理性γ-γ偶联，并显著增强了M1与lPM之间的反馈连接中的β-β偶联和θ-β偶联。从M1到lPM的交叉频率θ-β耦合增强与左旋多巴诱导的运动功能改善相关。结果表明，PD与运动前区和运动皮质区之间的神经通信改变有关，这可以通过多巴胺替代来调节。
Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.
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影响因子：
2.4
作者：
Ille, N;Berg, P;Scherg, M
通讯作者：
Scherg, M
DOI：
10.1016/s0924-980x(98)00045-9
发表时间：
1998-10-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Gerloff, C;Uenishi, N;Shibasaki, H
通讯作者：
Shibasaki, H
影响因子：
5.7
作者：
Chen, C. C.;Henson, R. N.;Friston, K. J.
通讯作者：
Friston, K. J.
影响因子：
14.5
作者：
Devos, D;Labyt, E;Defebvre, L
通讯作者：
Defebvre, L
影响因子：
5.7
作者：
Baker, Stuart N.
通讯作者：
Baker, Stuart N.