Assessment of coronary inflammation in antiretroviral treated people with HIV infection and active HIV/hepatitis C virus co-infection.
Assessment of coronary inflammation in antiretroviral treated people with HIV infection and active HIV/hepatitis C virus co-infection.
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DOI：
10.1097/qad.0000000000003125
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发表时间：
2022-03-01
期刊：
影响因子：
--
通讯作者：
Bagchi S
中科院分区：
文献类型：
--
作者：
Jeudy J;Patel P;George N;Burrowes S;Husson J;Chua J;Conn L;Weiss RG;Bagchi S
艾滋病毒感染者（PLWH）和丙型肝炎合并感染者（PLWH+HCV）患心血管疾病（CVD）的风险增加。冠状动脉周围炎症，通过冠状动脉CT血管造影（CCTA）的脂肪衰减指数（FAI）测量，独立预测一般人群的心血管风险，但尚未在PLWH+HCV人群中进行研究。我们测试了PLWH或PLWH+HCV患者冠状动脉周围炎症是否增加，以及炎症是否随时间变化。横断面分析确定各组间FAI差异。对PLWH进行纵向分析以评估炎症随时间的变化。年龄和性别匹配的血清阳性组（PLWH和PLWH+HCV）在抗逆转录病毒治疗（ART）、HCV病毒血症、无CVD病史和匹配对照组的病毒学抑制下接受CCTA治疗。在右冠状动脉近端（RCA）和左前降支（LAD）周围测量冠状动脉周围FAI。22例PLWH术后20.6 ~ 27.4个月行CCTA随访。101名参与者（48名女性）被研究（60名PLWH， 19名PLWH+HCV和22名对照）。在校正分析中，血清阳性组和对照组之间冠状动脉周围FAI没有差异。低衰减冠状动脉斑块在血清阳性组中的发生率明显低于对照组（LAD, p=0.035； RCA, p=0.017）。PLWH患者冠状动脉周围FAI值在基线和随访期间显著升高（RCA: p=0.001, LAD: p=<0.001）。通过FAI评估，与匹配的对照组相比，PLWH和PLWH+HCV没有CVD史，冠状动脉周围炎症没有明显加重。然而，单感染PLWH的冠状动脉周围炎症在大约22个月内显著增加。FAI测量可能是追踪PLWH无症状CVD进展的重要成像生物标志物。
Persons living with HIV (PLWH) and co-infected with hepatitis C (PLWH+HCV) have increased risk of cardiovascular disease (CVD). Peri-coronary inflammation, measured by fat attenuation index (FAI) on coronary CT angiography (CCTA), independently predicts cardiovascular risk in the general population but has not been studied in the PLWH+HCV population. We tested whether peri-coronary inflammation is increased in PLWH or PLWH+HCV, and whether inflammation changes over time. Cross-sectional analysis to determine FAI differences among groups. Longitudinal analysis in PLWH to assess changes in inflammation over time. Age- and sex-matched seropositive groups (PLWH and PLWH+HCV) virologically suppressed on antiretroviral therapy (ART), HCV viremic, and without prior CVD and matched controls underwent CCTA. Peri-coronary FAI was measured around the proximal right coronary artery (RCA) and left anterior descending artery (LAD). Follow-up CCTA was performed in 22 PLWH after 20.6–27.4 months. 101 participants (48 women) were studied (60 PLWH, 19 PLWH+HCV and 22 controls). In adjusted analyses, peri-coronary FAI did not differ between seropositive groups and controls. Low attenuation coronary plaque was significantly less common in seropositive groups compared to controls (LAD, p=0.035; and RCA, p=0.017, respectively). Peri-coronary FAI values significantly progressed between baseline and follow-up in PLWH (RCA: p=0.001, LAD: p=<0.001). PLWH and PLWH+HCV without history of CVD do not have significantly worse peri-coronary inflammation, assessed by FAI, compared to matched controls. However, peri-coronary inflammation in mono-infected PLWH significantly increased over approximately 22 months. FAI measures may be an important imaging biomarker for tracking asymptomatic CVD progression in PLWH.
影响因子：
3.4
作者：
Oguz A;Atay AE;Tas A;Seven G;Koruk M
通讯作者：
Koruk M