Predictive role of acute phase reactants in the response to therapy in patients with chronic hepatitis C virus infection.
Predictive role of acute phase reactants in the response to therapy in patients with chronic hepatitis C virus infection.
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DOI：
10.5009/gnl.2013.7.1.82
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发表时间：
2013-01
期刊：
影响因子：
3.4
通讯作者：
Koruk M
中科院分区：
文献类型：
--
作者：
Oguz A;Atay AE;Tas A;Seven G;Koruk M
生化指标和急性时相蛋白(APP)可能为慢性丙型肝炎(CHC)患者提供补充数据。我们的目标是评估APP在抗病毒治疗反应中的预测作用。45名患者接受了抗病毒治疗。在初始评估时、第4、12和48周检测血清铁蛋白、C反应蛋白(CRP)、转铁蛋白、白蛋白、α1酸性糖蛋白(A1AG)和α2巨球蛋白(A2 MG)水平。在初始评估时、第12周和第48周检测丙型肝炎病毒RNA水平。患者组的铁蛋白、转铁蛋白、A1AG和A2 MG水平显著升高(p<；0.05)。从基线到第4周，CRP、铁蛋白、A1AG和A2 MG水平显著升高(p<；0.05)。抗病毒治疗应答者和无效者在初始评估和第12周时的CRP、铁蛋白、转铁蛋白、A1AG、A2 MG和丙氨酸氨基转移酶(ALT)水平均无显著差异。铁蛋白、A1AG、A2 MG、白蛋白、C反应蛋白和转铁蛋白水平的变化不能替代病毒学和生化参数来预测CHC患者治疗的早期反应。然而，丙氨酸氨基转移酶水平和丙型肝炎病毒RNA结合急性期反应物的研究可能为评估抗病毒治疗的反应提供补充数据。
Biochemical parameters and acute-phase proteins (APPs) may provide complementary data in patients with chronic hepatitis C (CHC). We aimed to evaluate the predictive role of APPs in the response to antiviral therapy. Forty-five patients underwent antiviral therapy. Serum ferritin, C-reactive protein (CRP), transferrin, albumin, alpha-1 acid glycoprotein (A1AG), and alpha-2 macroglobulin (A2MG) levels were examined at the initial evaluation and at the 4th, 12th, and 48th weeks. HCV RNA levels were examined at the initial evaluation and at the 12th and 48th weeks. Ferritin, transferrin, A1AG, and A2MG levels were significantly higher in the patient group (p<0.05). CRP, ferritin, A1AG, and A2MG levels were significantly increased from baseline to the 4th week (p<0.05). The responders and nonresponders to antiviral therapy had insignificantly but remarkably different levels of CRP, ferritin, transferrin, A1AG, A2MG, and alanine aminotransferase (ALT) both at the initial evaluation and at the 12th week. Variations in ferritin, A1AG, A2MG, albumin, CRP, and transferrin levels are not alternatives to virological and biochemical parameters for predicting an early response to therapy in patients with CHC. However, the investigation of ALT levels and hepatitis C virus RNA in combination with acute-phase reactants may provide supplementary data for evaluating responses to antiviral therapy.
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影响因子：
11
作者：
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