Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma.
Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma.
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DOI：
10.1186/s12894-018-0334-7
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发表时间：
2018-03-27
期刊：
影响因子：
2
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Fang D;He S;Xiong G;Singla N;Cao Z;Zhang L;Li X;Zhou L
肾盆腔肿瘤与输尿管肿瘤在临床特征、病理结局、表观遗传生物标志物及预后等方面的差异尚无共识。回顾性分析1999 ~ 2011年间行根治性肾输尿管切除术的341例肾盆腔肿瘤患者和271例输尿管肿瘤患者的资料。比较两组患者的临床病理特征、基因启动子甲基化状态及肿瘤预后。进行回归分析以确定肿瘤预后因素。输尿管肿瘤患者年龄相对较大（p = 0.002），术前肾功能不全（p < 0.001）、高血压（p = 0.038）、肾积水（p < 0.001）的发生率较高，而肾盆腔肿瘤患者总体血尿发生率较高（p < 0.001）。肾盆腔肿瘤往往表现为非器官局限性病变（p = 0.004）和较大的肿瘤直径（p = 0.001），而输尿管肿瘤则更有可能表现为高分级（p < 0.001）和无根性结构（p = 0.023）。高甲基化基因启动子在肾盆腔肿瘤中更为普遍（p < 0.001），特别是TMEFF2、GDF15、RASSF1A、SALL3和ABCC6（均p < 0.05）。肿瘤位置不能独立预测癌症特异性生存、总生存、膀胱内或对侧复发（均p < 0.05），而基因甲基化状态被证明是一个独立的预后因素。肾盆腔肿瘤和输尿管肿瘤在临床病理特征和表观遗传生物标志物方面存在显著差异。基因启动子甲基化可能是解释UTUC中不同肿瘤模式和行为的重要机制。
There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis. The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared. Regression analysis was performed to identify oncologic prognosticators. Patients with ureteral tumors were relatively older (p = 0.002), and had higher likelihood of pre-operative renal insufficiency (p < 0.001), hypertension (p = 0.038) and hydronephrosis (P < 0.001), while in patients with renal pelvic tumors gross hematuria was more prevalent (p < 0.001). Renal pelvic tumors tended to exhibit non-organ-confined disease (p = 0.004) and larger tumor diameter (p = 0.001), while ureteral tumors had a higher likelihood of exhibiting high grade (p < 0.001) and sessile architecture (p = 0.023). Hypermethylated gene promoters were significantly more prevalent in renal pelvic tumors (p < 0.001), specifically for TMEFF2, GDF15, RASSF1A, SALL3 and ABCC6 (all p < 0.05). Tumor location failed to independently predict cancer-specific survival, overall survival, intravesical or contralateral recurrence (all p > 0.05), while gene methylation status was demonstrated to be an independent prognostic factor. Renal pelvic tumors and ureteral tumors exhibited significant differences in clinicopathologic characteristics and epigenetic biomarkers. Gene promoter methylation might be an important mechanism in explaining distinct tumor patterns and behaviors in UTUC.
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DOI：
10.1073/pnas.93.18.9821
发表时间：
1996-09-03
影响因子：
11.1
作者：
Herman, JG;Graff, JR;Baylin, SB
通讯作者：
Baylin, SB
影响因子：
8
作者：
Catto, JWF;Azzouzi, AR;Meuth, M
通讯作者：
Meuth, M
尿液沉积物中的一组新型 DNA 甲基化标记物用于膀胱癌的灵敏/特异性检测
影响因子：
11.5
作者：
Yu, Jian;Zhu, Tongyu;Zhu, Jingde
通讯作者：
Zhu, Jingde
影响因子：
11.5
作者：
Costa, Vera L.;Henrique, Rui;Lind, Guro E.
通讯作者：
Lind, Guro E.
表观遗传生物标志物和临床因素在上尿路尿路上皮癌的预后和预测价值。
影响因子：
3.8
作者：
Xiong, Gengyan;Liu, Jin;Zhou, Liqun
通讯作者：
Zhou, Liqun