Discharge of saccade-related superior colliculus neurons during saccades accompanied by vergence.
Discharge of saccade-related superior colliculus neurons during saccades accompanied by vergence.
复制标题
眼跳期间与眼跳相关的上丘神经元放电并伴有辐辏。
DOI：
10.1152/jn.00877.2002
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Mays,LawrenceE
中科院分区：
文献类型：
--
作者：
Walton,MarkMG;Mays,LawrenceE
长期以来，人们一直认为上丘（SC）参与眼跳的产生，但在眼球辐辏运动的产生中不起任何作用。然而，最近几项研究的结果表明，检查 SC 在眼跳-聚散相互作用中的作用可能是值得的。 具体来说，现有文献提出了两个问题：SC 中与眼跳相关的神经元是否具有三维运动场，以及因辐辏引起的眼跳减慢是否部分归因于 SC 活动水平的变化？记录了恒河猴 SC 中 51 个与眼跳相关的神经元在无聚散眼跳、伴有会聚的眼跳和伴有发散的眼跳期间的单单位数据。 当眼跳伴随着聚散时，大多数细胞（78% 为收敛，86% 为发散）表现出峰值尖峰密度显着降低。 少数细胞（16% 为收敛，2% 为发散）增加了眼跳的放电率并伴有辐辏。发现三种细胞的放电与眼跳、辐辏以及两者的组合有关。没有细胞表现出针对具有发散的眼跳而调整的细胞所预期的放电模式。因此，目前的结果并不支持与扫视相关的 SC 神经元通常在三个维度上进行调节的假设。对于近距离和远距离没有聚散的扫视，经常发现放电率存在微小但显着的差异。大约一半的细胞显示尖峰活动和眼跳速度之间存在显着关系，但相关性往往非常弱。这表明 SC 神经元的神经元活动减少对眼跳速度的影响有限。对于某些细胞来说，运动场会随着眼跳而发生变化。这些转变从一个细胞到另一个细胞的变化很大。
It has long been believed that the superior colliculus (SC) is involved in the production of saccades but plays no role in the generation of vergence eye movements. However, results from several recent studies suggest that it may be worthwhile to examine the role of the SC in saccade-vergence interactions. Specifically, the available literature suggests two questions: do saccade-related neurons in SC have three-dimensional movement fields and is the slowing of saccades by vergence attributable, in part, to changes in the level of activity in SC? Single-unit data were recorded from 51 saccade-related neurons in rhesus monkey SC during saccades without vergence, saccades accompanied by convergence, and saccades accompanied by divergence. Most cells (78% for convergence, 86% for divergence) showed a significant reduction in peak spike density when the saccade was accompanied by vergence. A minority of cells (16% for convergence, 2% for divergence) increased their firing rate for saccades accompanied by vergence. Three cells were found that discharged in association with saccades, vergence, and the combination of the two. There were no cells that exhibited the pattern of discharge that would be expected of a cell tuned for saccades with divergence. Thus the present results do not support the hypothesis that saccade-related SC neurons are, as a rule, tuned in three dimensions. Small, but significant, differences in firing rate were often found for saccades without vergence at near and far distances. Approximately half of the cells showed a significant relationship between spike activity and saccade velocity, but the correlations tended to be very weak. This suggests that the decreased neuronal activity of SC neurons has only a limited effect on saccade velocity. For some cells, the movement field shifted for saccades with vergence. These shifts were highly variable from one cell to another.
登录
查看更多内容
影响因子：
2.5
作者：
Quaia, C;Aizawa, H;Wurtz, RH
通讯作者：
Wurtz, RH
影响因子：
64.8
作者：
Gamlin, PD;Yoon, K
通讯作者：
Yoon, K
影响因子：
2.5
作者：
GNADT, JW;MAYS, LE
通讯作者：
MAYS, LE
影响因子：
1.8
作者：
Chaturvedi, V;vanGisbergen, JAM
通讯作者：
vanGisbergen, JAM
影响因子：
2.5
作者：
Goossens, HHLM;Van Opstal, AJ
通讯作者：
Van Opstal, AJ