Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study.
Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study.
复制标题
DOI：
10.1186/1471-2466-10-38
复制
发表时间：
2010-07-26
影响因子：
3.1
通讯作者：
Casas A
中科院分区：
文献类型：
--
作者：
Dennis RJ;Maldonado D;Rojas MX;Aschner P;Rondón M;Charry L;Casas A
血糖控制不足可能同时与2型糖尿病的炎症和肺功能下降有关。我们评估了血糖控制不佳患者的肺功能是否更差，以及这些受试者的炎症标志物是否同时增加。受试者在博戈塔的哥伦比亚糖尿病协会中心选择。进行肺功能检查，获得用力呼气量（FEV 1）、用力肺活量（FVC）和FEV 1/FVC的平均残差值，预测值基于Hankinson等人针对墨西哥裔美国人得出的值。多元最小二乘回归用于调整已知肺功能决定因素的差异。我们测量了糖化血红蛋白（HBA 1c）、白细胞介素6（IL-6）、肿瘤坏死因子（TNF-α）、纤维蛋白原、铁蛋白和C反应蛋白（C-RP）的血液水平。研究了495例糖尿病患者，其中352例控制不佳（HbA 1c> 7%）。在调整了已知的肺功能决定因素后，那些控制不佳的人FEV 1较低，（-75.4 mL，IC95%：-92，-59; P < 0.0001）和FVC（-121 mL，IC95%：-134，-108; P <0，0001）平均残差，FEV 1/FVC较高（0.013%，IC95%：0.009，0.018，P < 0.0001）残留，以及所有炎性标志物（IL-6除外）水平的增加（P < 0.05）。2型糖尿病和血糖控制不佳受试者的FVC和FEV 1低于预测值和血糖控制良好受试者。据推测，较差的肺功能可能与炎症介质水平升高有关。
Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control, and if inflammatory markers are simultaneously increased in these subjects. Subjects were selected at the Colombian Diabetes Association Center in Bogotá. Pulmonary function tests were performed and mean residual values were obtained for forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC, with predicted values based on those derived by Hankinson et al. for Mexican-Americans. Multiple least-squares regression was used to adjust for differences in known determinants of lung function. We measured blood levels of glycosylated hemoglobin (HBA1c), interleukin 6 (IL-6), tumor necrosis factor (TNF-α), fibrinogen, ferritin, and C-reactive protein (C-RP). 495 diabetic patients were studied, out of which 352 had inadequate control (HBA1c > 7%). After adjusting for known determinants of lung function, those with inadequate control had lower FEV1 (-75.4 mL, IC95%: -92, -59; P < 0.0001) and FVC (-121 mL, IC95%: -134, -108; P < 0,0001) mean residuals, and higher FEV1/FVC (0.013%, IC95%: 0.009, 0.018, P < 0.0001) residuals than those with adequate control, as well as increased levels of all inflammatory markers (P < 0.05), with the exception of IL-6. Subjects with type 2 diabetes and inadequate control had lower FVC and FEV1 than predicted and than those of subjects with adequate control. It is postulated that poorer pulmonary function may be associated with increased levels of inflammatory mediators.
登录
查看更多内容
DOI：
10.1164/ajrccm.163.2.2006158
发表时间：
2001-02-01
影响因子：
24.7
作者：
Sandford, AJ;Chagani, T;Paré, PD
通讯作者：
Paré, PD
影响因子：
5
作者：
McKeever, TM;Weston, PJ;Fogarty, A
通讯作者：
Fogarty, A
影响因子：
168.9
作者：
Fabbri, Leonardo M.;Rabe, Klaus F.
通讯作者：
Rabe, Klaus F.
影响因子：
16.2
作者：
Davis, WA;Knuiman, M;Davis, TME
通讯作者：
Davis, TME
影响因子：
10
作者：
Johnston, A. K.;Mannino, D. M.;Kiri, V. A.
通讯作者：
Kiri, V. A.