Vascular sodium pump activity kinetics in early and advanced stages of deoxycorticosterone-salt hypertension in rats.
Vascular sodium pump activity kinetics in early and advanced stages of deoxycorticosterone-salt hypertension in rats.
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大鼠脱氧皮质酮盐高血压早期和晚期的血管钠泵活动动力学。
DOI：
10.1016/0024-3205(91)90647-t
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Songu-Mize,E
中科院分区：
文献类型：
--
作者：
Songu-Mize,E
We determined the kinetic properties--the maximal velocity, Vmax, and the half-maximal activating concentration of K+, kmvalues--of the vascular sodium pump in rats 6, 28, and 50 days after deoxycorticosterone and sodium chloride (DOC-salt) or vehicle treatment. Tail arteries from six or eight rats from each treatment group were pooled, and Na-pump activity was measured in a Krebs medium containing varying K+(plus86Rb+) concentrations (0.25-10 mM). Na-pump activity was plotted as a function of [K +86Rb]. Data were fit to a two-site model to calculate Vmaxand kmvalues. Systolic blood pressures were normal after 6 days but high after 28 and 50 days of DOC-salt treatment. No difference in kinetic parameters existed between the treatment and control groups 6 and 50 days after DOC-salt treatment. After 28 days, Vmaxwas significantly elevated compared with controls; kmwas not affected. Thus, stimulation of the vascular Na-pump during established hypertension is due to an increase in the maximal velocity of ouabain-sensitive uptake of K+.
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钠钾三磷酸腺苷酶：药理学、生理学和生化方面。
影响因子：
21.1
作者：
A. Schwartz;G. Lindenmayer;J. Allen
通讯作者：
J. Allen
高血压中Na、K-ATP酶α亚基基因表达的亚型特异性调节。
DOI：
10.1126/science.2838907
发表时间：
1988
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Herrera,VL;Chobanian,AV;Ruiz-Opazo,N
通讯作者：
Ruiz-Opazo,N
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DOI：
10.1161/01.hyp.4.5.575
发表时间：
1982
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Songu-Mize,E;Bealer,SL;Caldwell,RW
通讯作者：
Caldwell,RW
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影响因子：
6
作者：
S. Friedman
通讯作者：
S. Friedman
大鼠的细胞通透性、钠转运和高血压过程
影响因子：
20.1
作者：
S. Friedman;C. L. Friedman
通讯作者：
C. L. Friedman