Effect of AV3V lesions on development of DOCA-salt hypertension and vascular Na+-pump activity.
Effect of AV3V lesions on development of DOCA-salt hypertension and vascular Na+-pump activity.
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AV3V 病变对 DOCA 盐高血压和血管钠泵活性发展的影响。
DOI：
10.1161/01.hyp.4.5.575
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Caldwell,RW
中科院分区：
文献类型：
--
作者：
Songu-Mize,E;Bealer,SL;Caldwell,RW
我们研究了第三脑室前腹侧（AV3V）病变对醋酸脱氧皮质酮盐（DOCA-salt）处理大鼠血管Na+泵活性的影响。对未治疗的对照大鼠、doca盐治疗大鼠、AV3V病变大鼠和doca盐治疗AV3V病变大鼠的血压和离体尾动脉Na+泵活性进行了测量，测量值为瓦阿巴因敏感的86rb摄取。接受DOCA治疗的对照组大鼠血压高于未接受DOCA治疗的大鼠。在给药前放置AV3V病变可防止血压升高。与所有其他组相比，doca治疗组的血管Na+泵活性降低了20%。AV3V病变阻止了DOCA治疗引起的Na+泵活性的抑制。血管Na+泵活性的抑制是由于一种体液物质，因为在doca盐处理的大鼠血浆中培养的对照大鼠尾动脉Na+泵活性比在对照血浆中培养的大鼠尾动脉Na+泵活性被抑制了25%。我们的研究结果支持这样的假设，即一种循环加压物质至少在一定程度上导致了DOCA盐高血压的发生，AV3V病变预防DOCA高血压的机制可能是通过阻断该因子的分泌、运输或合成。
We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity of deoxycorticosterone acetate-salt (DOCA-salt) treated rats. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive 86Rb-uptake, were determined in untreated control rats, DOCA-salt treated rats, rats with AV3V lesions, and rats with AV3V lesions which were treated with DOCA-salt. Control rats receiving DOCA treatment developed higher blood pressures than rats receiving no DOCA treatment. Placement of AV3V lesions prior to administration of DOCA prevented the increase in blood pressure. Vascular Na+-pump activity in the DOCA-treated group was reduced by 20% compared to all other groups. The AV3V lesions prevented the suppression of Na+-pump activity caused by DOCA treatment. Suppression of vascular Na+-pump activity was due to a humoral substance since Na+-pump activity of tail arteries from control rats incubated in plasma from DOCA-salt treated rats was suppressed by 25% when compared to those incubated in control plasma. Our findings support the hypothesis that a circulating pressor substance is at least partially responsible for the development of DOCA-salt hypertension and that the mechanism by which AV3V lesions prevent DOCA hypertension may be through the interruption of secretion, transport, or synthesis of this factor.
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DOI：
--
发表时间：
1979
期刊：
Life Science
影响因子：
--
作者：
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DOI：
10.1016/s0140-6736(00)61854-8
发表时间：
1940
期刊：
The Lancet
影响因子：
--
作者：
D. Y. Solandt;R. Nassim;C. R. Cowan
通讯作者：
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影响因子：
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DOI：
10.1161/01.hyp.4.1.132
发表时间：
1982
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Overbeck,HW;Grissette,DE
通讯作者：
Grissette,DE