Efficacy of hyaluronidase in reducing increases in intraocular pressure related to the use of viscoelastic substances.
Efficacy of hyaluronidase in reducing increases in intraocular pressure related to the use of viscoelastic substances.
复制标题
透明质酸酶在减少与使用粘弹性物质相关的眼压升高方面的功效。
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Refojo
中科院分区：
文献类型：
--
作者：
M. Harooni;J. Freilich;M. Abelson;M. Refojo
客观化
目的：评价透明质酸酶预防注射含透明质酸粘弹性物质引起的眼压升高的疗效。
方法
将25只大白兔随机分为5组。在第1至第4组中，双眼摘除0.15毫升房水，代之以0.10毫升粘弹性物质。另外，右眼前房注射10单位透明质酸酶(0.05mL)，左眼注射体积等量的平衡盐水。测试的粘弹性物质是Healon和Healon GV(Pharmacia&Upjohn，Kalamazoo，密歇根州)，Viscoat(Alcon实验室，德克萨斯州沃斯堡)和Ocucoat(Storz Ophthalmics，Clearwater，佛罗里达州)。第5组右眼注射10单位透明质酸酶，左眼注射平衡生理盐水。
结果
注射粘弹性物质后，眼压迅速升高，在注射后约46小时达到峰值，并在24小时内恢复到注射前水平。当与Healon、Healon GV和Viscoat联合使用时，透明质酸酶显著降低眼压，但与Ocucoat联合使用时不显著。在没有粘弹性的情况下注射时，透明质酸酶似乎降低了眼压，但这一结果没有统计学意义。
结论
兔前房内注射透明质酸酶可有效预防含透明质酸粘弹性物质引起的眼压升高。这种作用可能与透明质酸酶裂解透明质酸部分的能力有关。
OBJECTIVE
To evaluate the efficacy of hyaluronidase in preventing increases in intraocular pressure related to injections of hyaluronan-containing viscoelastic substances.
METHODS
Twenty-five white rabbits were divided into 5 groups. In groups 1 through 4, 0.15 mL of aqueous humor was removed and replaced with 0.10 mL of a viscoelastic substance in both eyes. Additionally, 10 units of hyaluronidase (0.05 mL) was injected in the anterior chamber of the right eye, whereas the left eye was injected with a volumetrically equivalent dose of balanced saline solution. Viscoelastic substances tested were Healon and Healon GV (Pharmacia & Upjohn, Kalamazoo, Mich), Viscoat (Alcon Laboratories, Fort Worth, Tex), and Ocucoat (Storz Ophthalmics, Clearwater, Fla). In group 5, right eyes were injected with 10 units of hyaluronidase and the left eyes were treated with balanced saline solution.
RESULTS
After injections of viscoelastic substance, intraocular pressure rose rapidly, reaching a peak at approximately 46 hours after injection and returning to preinjection levels within 24 hours. Hyaluronidase significantly decreased intraocular pressure when used with Healon, Healon GV, and Viscoat, but not with Ocucoat. When injected in the absence of viscoelastic, hyaluronidase appeared to decrease intraocular pressure, but this result was not statistically significant.
CONCLUSIONS
Injections of hyaluronidase into the anterior chamber of rabbits effectively prevent increases in intraocular pressure induced by hyaluronan-containing viscoelastic substances. This effect may be related to the ability of hyaluronidase to cleave hyaluronan moieties.
透明质酸钠、硫酸软骨素和甲基纤维素对角膜内皮和眼内压的影响。
影响因子：
4.2
作者：
MacRae,SM;Edelhauser,HF;Hyndiuk,RA;Burd,EM;Schultz,RO
通讯作者：
Schultz,RO
前房粘性溶液的功效和毒性以及眼压反应的比较。
DOI：
10.1001/archopht.1986.01050240093047
发表时间：
1986
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Glasser,DB;Matsuda,M;Edelhauser,HF
通讯作者：
Edelhauser,HF
影响因子：
4.4
作者：
Gottlieb,JL;Antoszyk,AN;Hatchell,DL;Saloupis,P
通讯作者：
Saloupis,P