From equator to pole: splitting chromosomes in mitosis and meiosis.
From equator to pole: splitting chromosomes in mitosis and meiosis.
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DOI：
10.1101/gad.255554.114
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发表时间：
2015-01-15
影响因子：
10.5
通讯作者：
Marston AL
中科院分区：
文献类型：
--
作者：
Duro E;Marston AL
在真核细胞分裂过程中，染色体必须精确地划分到子细胞。这依赖于一种在亲本细胞内沿确定方向移动染色体的机制。当姐妹染色单体在有丝分裂和减数分裂II中彼此分离时，特定的适应性使同源染色体在减数分裂I中分离以减少配子产生的倍性。许多驱动这些定向染色体运动的因素是已知的，它们的分子机制已经开始被揭示。在这里，我们回顾了真核生物染色体分离的机制，特别强调了在减数分裂I期间确保同源染色体分离的修饰。
During eukaryotic cell division, chromosomes must be precisely partitioned to daughter cells. This relies on a mechanism to move chromosomes in defined directions within the parental cell. While sister chromatids are segregated from one another in mitosis and meiosis II, specific adaptations enable the segregation of homologous chromosomes during meiosis I to reduce ploidy for gamete production. Many of the factors that drive these directed chromosome movements are known, and their molecular mechanism has started to be uncovered. Here we review the mechanisms of eukaryotic chromosome segregation, with a particular emphasis on the modifications that ensure the segregation of homologous chromosomes during meiosis I.
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