A Pathophysiological Intersection of Diabetes and Alzheimer's Disease.

A Pathophysiological Intersection of Diabetes and Alzheimer's Disease.
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DOI:
10.3390/ijms231911562
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发表时间:
2022-09-30
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
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--
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糖尿病是现代世界最普遍的疾病之一,与多种神经退行性疾病的风险增加密切相关,尽管确切的病理生理机制尚不清楚。胰岛素抵抗是一种严重的病理状况,与 2 型糖尿病、代谢综合征和肥胖有关。最近,胰岛素抵抗已被证明与认知能力下降和痴呆症有关,包括最常见的阿尔茨海默病。糖尿病和阿尔茨海默病之间在病理生理学方面的关系非常重要,以至于有人建议将该病的某些表现称为 3 型糖尿病。
Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes.
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