Overdose prevention and naloxone prescription for opioid users in San Francisco.
Overdose prevention and naloxone prescription for opioid users in San Francisco.
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旧金山阿片类药物用户的预防过量预防和纳洛酮处方。
DOI：
10.1007/s11524-010-9495-8
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发表时间：
2010-12
影响因子：
6.6
通讯作者：
Bamberger, Joshua D.
中科院分区：
文献类型：
--
作者：
Enteen, Lauren;Bauer, Joanna;McLean, Rachel;Wheeler, Eliza;Huriaux, Emalie;Kral, Alex H.;Bamberger, Joshua D.
阿片类药物过量是美国注射吸毒者（IDUs）死亡的一个重要原因。阿片类药物过量可通过给予纳洛酮（一种阿片类药物拮抗剂）逆转。在注射吸毒者中，目睹过量事件的发生率很高，向注射吸毒者提供带回家的纳洛酮可能是减少过量死亡人数的重要干预措施。药物过量预防和教育（DOPE）项目是与县卫生部门（弗朗西斯科公共卫生部）合作建立的第一个纳洛酮处方计划（NPP），是美国运行时间最长的NPP之一。从2003年9月至2009年12月，1，942人通过DOPE项目接受了培训和处方纳洛酮，其中24%返回接受纳洛酮补充，11%报告在过量事件期间使用纳洛酮。在使用纳洛酮的399起过量事件中，参与者报告89%被逆转。此外，83%报告过量逆转的参与者将逆转归因于他们的纳洛酮给药，不到1%的人报告了严重的不良反应。DOPE项目的研究结果增加了越来越多的研究，这些研究表明，目睹过量事件的高风险注射吸毒者愿意接受过量应对策略的培训，并在过量事件期间使用带回家的纳洛酮以防止死亡。
Opiate overdose is a significant cause of mortality among injection drug users (IDUs) in the United States (US). Opiate overdose can be reversed by administering naloxone, an opiate antagonist. Among IDUs, prevalence of witnessing overdose events is high, and the provision of take-home naloxone to IDUs can be an important intervention to reduce the number of overdose fatalities. The Drug Overdose Prevention and Education (DOPE) Project was the first naloxone prescription program (NPP) established in partnership with a county health department (San Francisco Department of Public Health), and is one of the longest running NPPs in the USA. From September 2003 to December 2009, 1,942 individuals were trained and prescribed naloxone through the DOPE Project, of whom 24% returned to receive a naloxone refill, and 11% reported using naloxone during an overdose event. Of 399 overdose events where naloxone was used, participants reported that 89% were reversed. In addition, 83% of participants who reported overdose reversal attributed the reversal to their administration of naloxone, and fewer than 1% reported serious adverse effects. Findings from the DOPE Project add to a growing body of research that suggests that IDUs at high risk of witnessing overdose events are willing to be trained on overdose response strategies and use take-home naloxone during overdose events to prevent deaths.
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影响因子：
4.4
作者：
Galea, Sandro;Worthington, Nancy;Rosenthal, David M.
通讯作者：
Rosenthal, David M.
影响因子：
6
作者：
Strang, John;Manning, Victoria;Semmler, Claudia
通讯作者：
Semmler, Claudia
影响因子：
4.2
作者：
Sherman, Susan G.;Cheng, Yingkai;Kral, Alexander H.
通讯作者：
Kral, Alexander H.
DOI：
10.1093/jurban/jtg032
发表时间：
2003-06-01
影响因子：
6.6
作者：
Seal, KH;Downing, M;Edlin, BR
通讯作者：
Edlin, BR
影响因子：
6
作者：
Green, Traci C.;Heimer, Robert;Grau, Lauretta E.
通讯作者：
Grau, Lauretta E.