Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?
Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller?
复制标题
趋化因子受体CXCR2：生理调节剂和神经炎症控制剂？
DOI：
10.1016/j.jneuroim.2012.02.016
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发表时间：
2012-05-15
影响因子：
3.3
通讯作者：
Ransohoff, Richard M.
中科院分区：
文献类型：
--
作者：
Veenstra, Mike;Ransohoff, Richard M.
先天免疫系统是炎症反应的重要组成部分，而中枢神经系统(CNS)是机体最容易受到炎症组织损伤的部位。神经炎性脑病是一种中枢神经系统受到自身免疫系统威胁的疾病。趋化因子受体CXCR2及其配体与多种神经炎性脑病、中性粒细胞募集和神经细胞的发育定位有关。本文就CXCR2的基础、在骨髓中性粒细胞募集中的调节作用、少突胶质细胞前体细胞定位和神经修复机制以及在神经炎性脑病理中的不同作用作一综述。
The innate immune system is a crucial component of inflammatory reactions, while the central nervous system (CNS) is the most vulnerable site of the body to inflammatory tissue injury. Neuroinflammatory brain pathologies are disorders in which the CNS is threatened by its own immune system. Chemokine receptor CXCR2 and its ligands have been implicated in several neuroinflammatory brain pathologies, as well as in neutrophil recruitment and in the developmental positioning of neural cells. This review focuses on the basics of CXCR2, its regulating role in bone marrow neutrophil recruitment, oligodendrocyte progenitor cell positioning and neural repair mechanisms, as well as its diverse roles in neuroinflammatory brain pathologies.
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