The Bacillus subtilis DnaD protein: a putative link between DNA remodeling and initiation of DNA replication.
The Bacillus subtilis DnaD protein: a putative link between DNA remodeling and initiation of DNA replication.
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DOI:
10.1016/j.febslet.2004.10.051
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发表时间:
2004-11-19
期刊:
影响因子:
3.5
通讯作者:
Soultanas, P
中科院分区:
文献类型:
--
作者:
Turner, IJ;Scott, DJ;Allen, S;Roberts, CJ;Soultanas, P
The Bacillus subtilis DnaD protein is an essential protein and a component of the oriC and PriA primosomal cascades, which are responsible for loading the main replicative ring helicase DnaC onto DNA. We present evidence that DnaD also has a global DNA architectural activity, assembling into large nucleoprotein complexes on a plasmid and counteracting plasmid compaction in a manner analogous to that recently seen for the histone-like Escherichia coli HU proteins. This DNA-remodeling role may be an essential function for initiation of DNA replication in the Gram +ve B. subtilis, thus highlighting DnaD as the link between bacterial nucleoid reorganization and initiation of DNA replication.
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影响因子:
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DOI:
10.1073/pnas.84.3.653
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