Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand.
Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand.
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DOI：
10.1292/jvms.13-0642
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Muramatsu Y
中科院分区：
文献类型：
--
作者：
Uchida L;Heriyanto A;Thongchai C;Hanh TT;Horiuchi M;Ishihara K;Tamura Y;Muramatsu Y
有关牛海绵状脑病(BSE)易感性的基因插入/缺失(INDEL)多态频率和编码区八肽重复数和单核苷酸多态(SNPs)的信息已经积累。本研究调查了越南、印度尼西亚和泰国牛和水牛PRNP启动子区域23bpIndel多态和内含子1区域12bpIndel多态、八肽重复序列多态和SNPs的频率。23indel位点的缺失等位基因在印度尼西亚和泰国的黄牛和水牛中的频率明显较低。在每个亚群的所有牛和水牛中，12indel位点的缺失等位基因频率显著较低。据报道，在这两个插入位点上，缺失等位基因与经典型疯牛病的易感性有关。在印尼一些地方黄牛品种中，含有5个八肽重复的等位基因的频率非常高，尽管有报道称具有6个八肽重复的等位基因在许多品种的牛中最常见。在印度尼西亚当地牛身上发现的四个SNPs尚未报告用于家牛。这项研究提供了关于这些东南亚国家家畜PRNP的信息。
There has been an accumulation of information on frequencies of insertion/deletion (indel) polymorphisms within the bovine prion protein gene (PRNP) and on the number of octapeptide repeats and single nucleotide polymorphisms (SNPs) in the coding region of bovine PRNP related to bovine spongiform encephalopathy (BSE) susceptibility. We investigated the frequencies of 23-bp indel polymorphism in the promoter region (23indel) and 12-bp indel polymorphism in intron 1 region (12indel), octapeptide repeat polymorphisms and SNPs in the bovine PRNP of cattle and water buffaloes in Vietnam, Indonesia and Thailand. The frequency of the deletion allele in the 23indel site was significantly low in cattle of Indonesia and Thailand and water buffaloes. The deletion allele frequency in the 12indel site was significantly low in all of the cattle and buffaloes categorized in each subgroup. In both indel sites, the deletion allele has been reported to be associated with susceptibility to classical BSE. In some Indonesian local cattle breeds, the frequency of the allele with 5 octapeptide repeats was significantly high despite the fact that the allele with 6 octapeptide repeats has been reported to be most frequent in many breeds of cattle. Four SNPs observed in Indonesian local cattle have not been reported for domestic cattle. This study provided information on PRNP of livestock in these Southeast Asian countries.
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