Breaking the Gingival Epithelial Barrier: Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease.
Breaking the Gingival Epithelial Barrier: Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease.
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DOI：
10.3390/cells3020476
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发表时间：
2014-05-23
期刊：
影响因子：
6
通讯作者：
DiRienzo JM
中科院分区：
文献类型：
--
作者：
DiRienzo JM
革兰氏阴性细菌伴放线菌聚集杆菌是引起感染性心内膜炎的HACEK组的一部分，是促进某些形式的牙周病的口腔植物群的组分，也是分泌细胞致死性膨胀毒素（Cdt）的物种家族的成员。表达cdt基因的细菌家族参与涉及粘膜或上皮层破坏的疾病。体外研究表明，人牙龈上皮细胞（HGEC）是Cdt的天然靶标，Cdt通常诱导DNA损伤，在细胞周期的G2/M间期发出生长停滞信号。牙龈上皮是口腔中抵抗微生物侵袭的早期防线。当受损时，细菌集体进入下层结缔组织，其中微生物产物可以影响浸润炎性细胞的过程和途径，最终破坏牙齿的附着装置。一种方法是使用离体牙龈外植体模型来评估Cdt对组织形态和完整性的影响。本综述的目的是提供这些研究的概述，并严格审查的潜在贡献的CDT的保护牙龈屏障的崩溃。
The Gram-negative bacterium Aggregatibacter actinomycetemcomitans is part of the HACEK group that causes infective endocarditis, a constituent of the oral flora that promotes some forms of periodontal disease and a member of the family of species that secrete a cytolethal distending toxin (Cdt). The family of bacteria that express the cdt genes participate in diseases that involve the disruption of a mucosal or epithelial layer. In vitro studies have shown that human gingival epithelial cells (HGEC) are native targets of the Cdt that typically induces DNA damage that signals growth arrest at the G2/M interphase of the cell cycle. The gingival epithelium is an early line of defense in the oral cavity against microbial assault. When damaged, bacteria collectively gain entry into the underlying connective tissue where microbial products can affect processes and pathways in infiltrating inflammatory cells culminating in the destruction of the attachment apparatus of the tooth. One approach has been the use of an ex vivo gingival explant model to assess the effects of the Cdt on the morphology and integrity of the tissue. The goal of this review is to provide an overview of these studies and to critically examine the potential contribution of the Cdt to the breakdown of the protective gingival barrier.
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
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作者：
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