URB597 induces subtle changes to aggression in adult Lister Hooded rats.
URB597 induces subtle changes to aggression in adult Lister Hooded rats.
复制标题
DOI：
10.3389/fpsyt.2022.885146
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Stubbendorff, Christine
中科院分区：
文献类型：
--
作者：
Warren, William G.;Hale, Ed;Papagianni, Eleni P.;Cassaday, Helen J.;Stevenson, Carl W.;Stubbendorff, Christine
内源性大麻素系统与社会和认知过程有关。内源性大麻素代谢抑制剂URB 597剂量依赖性地改善成年Wistar和Sprague道利大鼠的非社会记忆，而其对社会互动（SI）的影响受大鼠品系和药物剂量的影响。与白化病品系相比，Lister Hooded大鼠通常对药物治疗的反应不同。本研究旨在研究不同剂量的URB 597对Lister Hooded大鼠社会和非社会记忆的影响，以及分析SI的行为组成。测试雄性动物的新物体识别（NOR）、社会偏好（物体和不熟悉的大鼠之间）、社会新奇识别（熟悉与不熟悉的大鼠）和与不熟悉的大鼠的SI。测试前30分钟给予URB 597（0.1或0.3 mg/kg）或溶剂。在SI测试中，总互动时间与攻击性和探索性行为所花费的时间一起进行了沿着评估。Lister Hooded大鼠表现出预期的非社会和社会记忆和社会偏好，这不受URB 597的影响。在SI期间，URB 597不影响总交互时间。然而，与媒介物相比，高剂量增加了攻击性，并且与低剂量的URB 597相比减少了肛门生殖器嗅闻。总之，URB 597不影响NOR、社会偏好或社会识别记忆，但在Lister hooded大鼠的SI期间确实具有微妙的行为影响。根据我们的研究结果，我们认为，在调查药物对社会行为的影响时，考虑压力以及行为的详细组成的重要性。
The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on social interaction (SI) is affected by both rat strain and drug dose. Lister Hooded rats consistently respond differently to drug treatment in general compared with albino strains. This study sought to investigate the effects of different doses of URB597 on social and non-social memory in Lister Hooded rats, as well as analyzing the behavioral composition of the SI. Males were tested for novel object recognition (NOR), social preference (between an object and an unfamiliar rat), social novelty recognition (for a familiar vs. unfamiliar rat) and SI with an unfamiliar rat. URB597 (0.1 or 0.3 mg/kg) or vehicle was given 30 min before testing. During SI testing, total interaction time was assessed along with time spent on aggressive and explorative behaviors. Lister Hooded rats displayed expected non-social and social memory and social preference, which was not affected by URB597. During SI, URB597 did not affect total interaction time. However, the high dose increased aggression, compared to vehicle, and decreased anogenital sniffing, compared to the low dose of URB597. In summary, URB597 did not affect NOR, social preference or social recognition memory but did have subtle behavioral effects during SI in Lister hooded rats. Based on our findings we argue for the importance of considering strain as well as the detailed composition of behavior when investigating drug effects on social behavior.
登录
查看更多内容
影响因子：
2.2
作者：
Cyrenne, De-Laine M.;Brown, Gillian R.
通讯作者：
Brown, Gillian R.
影响因子：
7.6
作者：
Kohli, Shivali;King, Madeleine V.;Fone, Kevin C. F.
通讯作者：
Fone, Kevin C. F.
影响因子：
3.6
作者：
Hasanein, Parisa;Far, Massoud Teimuri
通讯作者：
Far, Massoud Teimuri
影响因子：
5
作者：
Chang CH;Liu YC;Sun CY;Su CL;Gean PW
通讯作者：
Gean PW
影响因子：
3.7
作者：
Manahan-Vaughan, D
通讯作者：
Manahan-Vaughan, D