Ontogeny of sex differences in response to novel objects from adolescence to adulthood in lister-hooded rats.
Ontogeny of sex differences in response to novel objects from adolescence to adulthood in lister-hooded rats.
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DOI：
10.1002/dev.20542
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发表时间：
2011-11
影响因子：
2.2
通讯作者：
Brown, Gillian R.
中科院分区：
文献类型：
--
作者：
Cyrenne, De-Laine M.;Brown, Gillian R.
在人类中，寻求新奇的行为在青春期达到顶峰，男性比女性更高。相对而言，关于啮齿动物对新奇事物反应的年龄和性别差异的信息很少。在本研究中，在青春期早期（出生后，pnd，28）、青春期中期（pnd 40）或成年早期（pnd 80）对雄性和雌性Lister-hooded大鼠进行了新物体识别任务测试（每个年龄组n = 12只雄性/雌性）。在青春期中期，男性对新奇事物的偏好高于女性，而在青春期早期没有性别差异。成年女性比成年男性更喜欢与新对象互动，但当侧偏被去除时，情况并非如此。在青春期中期的性别差异没有发现在其他措施，这表明在这个年龄段的差异是特定的情况下，涉及选择的新奇。这些结果被认为是在性腺激素和多巴胺系统之间的年龄和性别依赖的相互作用的背景下。© 2011 Wiley Periodicals，Inc. Dev Psychobiol 53：670-676，2011.
In humans, novelty-seeking behavior peaks in adolescence and is higher in males than females. Relatively, little information is available regarding age and sex differences in response to novelty in rodents. In this study, male and female Lister-hooded rats were tested at early adolescence (postnatal day, pnd, 28), mid-adolescence (pnd 40), or early adulthood (pnd 80) in a novel object recognition task (n = 12 males/females per age group). Males displayed a higher preference for the novel object than females at mid-adolescence, with no sex difference at early adolescence. Adult females interacted with the novel object more than adult males, but not when side biases were removed. Sex differences at mid-adolescence were not found in other measures, suggesting that the difference at this age was specific to situations involving choice of novelty. The results are considered in the context of age- and sex-dependent interactions between gonadal hormones and the dopamine system. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:670–676, 2011.
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影响因子：
2.2
作者：
Moore, Eileen M.;Linsenbardt, David N.;Boehm, Stephen L., II
通讯作者：
Boehm, Stephen L., II
影响因子：
2.7
作者：
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通讯作者：
DELACOUR, J
影响因子：
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作者：
Ghi, P;Orsetti, M;Ferretti, C
通讯作者：
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影响因子：
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作者：
Calamandrei, G;Rufini, O;Puopolo, M
通讯作者：
Puopolo, M
DOI：
10.1196/annals.1308.003
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Kelley, AE;Schochet, T;Landry, CF
通讯作者：
Landry, CF