Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets.
Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets.
复制标题
使用环脑雪貂研究大脑皮层发育和进化的机制。
DOI：
10.3389/fcell.2022.847159
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发表时间：
2022
影响因子：
5.5
通讯作者：
Kawasaki H
中科院分区：
文献类型：
--
作者：
Shinmyo Y;Hamabe-Horiike T;Saito K;Kawasaki H
哺乳动物的大脑皮层在进化过程中发生了显著变化。由于大脑皮层中神经元和神经胶质细胞数量的增加，其体积显著增大。此外，大脑皮层表面出现了褶皱，即脑回和脑沟，其神经元回路也变得复杂得多。尽管这些进化过程中的变化被认为对获得高级脑功能至关重要，但哺乳动物大脑皮层发育和进化的潜在机制仍不清楚。这至少部分是因为仅用小鼠难以研究这些机制。因此，最近开发出了针对有脑回的食肉动物雪貂大脑皮层的基因操作技术。此外，利用CRISPR/Cas9系统在雪貂大脑皮层中实现了基因敲除。这些技术使得能够利用雪貂大脑皮层进行分子层面的研究。在这篇综述中，我们将总结关于哺乳动物大脑皮层发育和进化潜在机制的最新研究成果，主要聚焦于以雪貂为对象的研究。
The mammalian cerebral cortex has changed significantly during evolution. As a result of the increase in the number of neurons and glial cells in the cerebral cortex, its size has markedly expanded. Moreover, folds, called gyri and sulci, appeared on its surface, and its neuronal circuits have become much more complicated. Although these changes during evolution are considered to have been crucial for the acquisition of higher brain functions, the mechanisms underlying the development and evolution of the cerebral cortex of mammals are still unclear. This is, at least partially, because it is difficult to investigate these mechanisms using mice only. Therefore, genetic manipulation techniques for the cerebral cortex of gyrencephalic carnivore ferrets were developed recently. Furthermore, gene knockout was achieved in the ferret cerebral cortex using the CRISPR/Cas9 system. These techniques enabled molecular investigations using the ferret cerebral cortex. In this review, we will summarize recent findings regarding the mechanisms underlying the development and evolution of the mammalian cerebral cortex, mainly focusing on research using ferrets.
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影响因子：
16.6
作者：
Chizhikov, Victor V.;Iskusnykh, Igor Y.;Millen, Kathleen J.
通讯作者：
Millen, Kathleen J.
影响因子：
16.2
作者：
Arcila ML;Betizeau M;Cambronne XA;Guzman E;Doerflinger N;Bouhallier F;Zhou H;Wu B;Rani N;Bassett DS;Borello U;Huissoud C;Goodman RH;Dehay C;Kosik KS
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Kosik KS
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64.5
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通讯作者：
Haussler D
影响因子：
7.7
作者：
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通讯作者：
Hiller, Michael
影响因子：
3
作者：
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通讯作者：
Borrell, Victor