Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.
Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.
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DOI：
10.1016/j.neuron.2014.01.017
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发表时间：
2014-03-19
期刊：
影响因子：
16.2
通讯作者：
Kosik KS
中科院分区：
文献类型：
--
作者：
Arcila ML;Betizeau M;Cambronne XA;Guzman E;Doerflinger N;Bouhallier F;Zhou H;Wu B;Rani N;Bassett DS;Borello U;Huissoud C;Goodman RH;Dehay C;Kosik KS
非灵长类和灵长类在皮质发生方面的主要差异包括生发区(GZ)的大小、前体谱系和发育时间。对E80猕猴胚胎视皮层GZ区和皮质板的microRNAs(MiRNAs)进行了深度测序。17区CP和GZ包括室区(VZ)、外室下区(OSVZ)的外亚室和内侧亚室，显示出独特的miRNA图谱。MiRNAs在灵长类动物中存在，但在啮齿动物中不存在，这对GZ亚区之间的差异表达起到了不成比例的作用。在这些miRNAs的有效靶标中，突出的是细胞周期和神经发生调节因子。新出现的miRNAs和它们的靶标之间的共同进化表明，新的miRNAs整合到了古老的基因电路中，对增殖施加了额外的控制。我们得出结论，多个细胞周期调节事件有助于灵长类特定皮质特征的出现，包括OSVZ，产生扩大的颗粒上层，这在很大程度上是灵长类皮质计算能力增强的原因。
Major non primate-primate differences in corticogenesis include the dimensions, precursor lineages and developmental timing of the germinal zones (GZ). microRNAs (miRNAs) of laser dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including Ventricular Zone (VZ), outer and inner subcompartments of the Outer SubVentricular Zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ sub-regions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Co-evolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1073/pnas.1218887109
发表时间：
2012-12-11
影响因子：
11.1
作者：
Cambronne, Xiaolu A.;Shen, Rongkun;Goodman, Richard H.
通讯作者：
Goodman, Richard H.
影响因子：
3.7
作者：
Garcia-Moreno, Fernando;Vasistha, Navneet A.;Molnar, Zoltan
通讯作者：
Molnar, Zoltan
人类，狗和小鼠的系统基因组研究。
影响因子：
4.3
作者：
Cannarozzi, Gina;Schneider, Adrian;Gonnet, Gaston
通讯作者：
Gonnet, Gaston
影响因子：
4.1
作者：
Hou, Zhuo-cheng;Romero, Roberto;Wildman, Derek E.
通讯作者：
Wildman, Derek E.