Stromal-dependent tumor promotion by MIF family members.

Stromal-dependent tumor promotion by MIF family members.
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DOI:
10.1016/j.cellsig.2014.09.012
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发表时间:
2014-12
影响因子:
4.8
通讯作者:
Yaddanapudi K
Yaddanapudi K
中科院分区:
生物学2区
文献类型:
--
作者:
Mitchell RA;Yaddanapudi K

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实体瘤是由一群不同种类的细胞组成的,这些细胞相互作用,并与可溶和不可溶的因素相结合,这些因素结合在一起,强烈影响恶性肿瘤的相对增殖、分化、运动、基质重塑、代谢和微血管密度。一个与肿瘤微环境中的前肿瘤表型越来越相关的可溶性因子家族是迁移抑制因子家族,该家族包括其同名成员MIF及其唯一已知的家族成员D-DOPAChrome互变删除酶(D-DT)。这篇综述旨在强调我们目前对各种免疫和非免疫肿瘤基质细胞群体的相对贡献的理解,并在这些背景下总结与MIF和/或D-DT相关的文献。
Solid tumors are composed of a heterogeneous population of cells that interact with each other and with soluble and insoluble factors that, when combined, strongly influence the relative proliferation, differentiation, motility, matrix remodeling, metabolism and microvessel density of malignant lesions. One family of soluble factors that is becoming increasingly associated with pro-tumoral phenotypes within tumor microenvironments is that of the migration inhibitory factor family which includes its namesake, MIF, and its only known family member, D-dopachrome tautomerase (D-DT). This review seeks to highlight our current understanding of the relative contributions of a variety of immune and non-immune tumor stromal cell populations and, within those contexts, will summarize the literature associated with MIF and/or D-DT.
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